Primary Salivary Gland–Type Lung Cancer: Clinicopathological Analysis of 88 Cases from China

Epithelial–myoepthelial carcinoma of the tracheobronchial tree: The prognostic role of myoepithelial cells

Primary epithelial myoepithelial carcinoma of lung is a rare entity and is thought to arise from the submucosal bronchial glands distributed throughout the lower respiratory tract. Because of the rarity of this tumor, we describe one case of epithelial myoepithelial carcinoma arising in the bronchus intermedius and presenting as an endobronchial mass. A 57-year-old male patient presented with an incidental finding of an endobronchial mass located in the lumen of the right lower lobe bronchus and caused near total luminal occlusion of the bronchus. An endobronchial carcinoid tumor was entertained clinically. Subsequently the patient underwent an uneventful videothoracoscopic lobectomy of lower and middle lobes of the right lung. Morphologically and immunohistochemically the tumor was characterized by two cell populations with epithelial and myoepithelial cells forming duct-like structure. The final diagnosis of epithelial myoepithelial carcinoma of lung was rendered.

/pdf/primary-epithelial-myoepithelial-carcinoma-of-lung-reporting-zhh69ank16.pdf

Primary Epithelial Myoepithelial Carcinoma of Lung, Reporting of a Rare Entity, Its Molecular Histogenesis and Review of the Literature

Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. Epithelial-myoepithelial carcinoma (EMCa) is a low-grade malignant tumour. According to literature, most commonly occurs in salivary glands, particularly in parotic gland, but it can also occur in unusual locations such as breast, lachrymal gland, nose, paranasal sinus, lung, bronchus and, as in our case, trachea. There are no many documented case reports of a primary myoepithelial carcinoma in the trachea. We report a case of a 34-year-old man diagnosed with this unusual location of an epithelial-myoepithelial tumor. The tumour was removed by segmental tracheal resection and end-to-end anastomosis.

/pdf/epithelial-myoepithelial-carcinoma-of-the-trachea-a-rare-50yf69hjj3.pdf

Epithelial-myoepithelial carcinoma of the trachea—a rare entity case report

Pulmonary epithelial-myoepithelial carcinoma (P-EMC) is a rare subset of salivary gland-type tumors of the lung Because of its rarity and unproven malignant potential, the optimal therapy for P-EMC has not been defined Here, we report a typical case of P-EMC and a review of the literature to consider appropriate treatment A 54-year-old woman presented with an abnormal lung shadow on a routine chest X-ray A chest computed tomography (CT) scan verified an 18-mm endobronchial nodule on the middle lobe We performed a bronchoscopic biopsy, and the patient was diagnosed with P-EMC After confirming the absence of tumors in the salivary glands, she underwent a right middle lobectomy along with hilar and mediastinal lymph node dissections Currently, the patient is doing well, without any sign of recurrence 3 years after surgery Although a majority of P-EMC cases, as in our case, behave indolently, several poor progression cases have been reported For distinguishing the minor malignancy cases from others, histological findings such as myoepithelial anaplasia could be a predictive factor Complete resection is needed to evaluate the whole tumor, because P-EMCs often show histological heterogeneity Moreover, incomplete excision may be a poor prognostic factor Although lobectomies as well as lymph node dissections, sleeve lobectomies, or pneumonectomies are routinely performed for complete resection, further investigation is required to establish the optimal treatment strategy

/pdf/epithelial-myoepithelial-carcinoma-of-the-lung-a-case-report-48xfq2kmkq.pdf

Epithelial-myoepithelial carcinoma of the lung: a case report

Tracheobronchial submucous glands can be considered the pulmonary equivalent of minor salivary glands and therefore they can develop most of the tumours originated in these. Nevertheless, in spite of the wide distribution of this kind of glands along the tracheobronchial tree, pulmonary salivary gland-like neoplasms are not very frequent. Among them, the most frequent are mucoepidermoid and adenoid cystic carcinomas. On the contrary, pulmonary neoplasms showing a mixture of epithelial and myoepithelial elements are extraordinary infrequent, with only 11 cases collected from literature. We present the case of a 76 year-old woman with no interesting pathological history, to whom a pulmonary nodule is detected during a study of unknown origin neutropenia. An upper right lobectomy is performed. After macro and microscopic study, the diagnosis of pulmonary epithelial-myoepithelial tumour is made. It is a low malignant potential tumour with capacity to locally recur and less frequently to metastasize. Our case has the peculiarity of not being connected neither to visceral pleura nor to bronchial tree; we have not found this characteristic in any literature reviewed case. These tumours have been named in a lot of different ways, including adenomyoepithelioma, epithelial-myoepithelial tumour, epithelial-myoepithelial carcinoma or epithelial-myoepithelial tumour of uncertain malignant potential. The p27/kip-1 protein plays a fundamental role in the development of these neoplasms. As we have verified in our case, its aberrant cytoplasmic location, besides its proved oncogenic function, would favour the proliferation of stem cells, which would explain both dual phenotype with presence of myoepithelial cells without connection with the bronchial tree, and TTF-1 immunostaining in epithelial cells.

/pdf/epithelial-myoepithelial-tumour-of-the-lung-a-case-report-26gosexpj4.pdf

Epithelial-myoepithelial tumour of the lung: a case report referring to its molecular histogenesis

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Epithelial-myoepithelial tumour of the lung: a case report referring to its molecular histogenesis