Guillermo J. Tearney
Harvard University
569 Papers
10.6K Citations
Guillermo J. Tearney is an academic researcher from Harvard University. The author has contributed to research in topics: Optical coherence tomography & Medicine. The author has an hindex of 114, co-authored 523 publications. Previous affiliations of Guillermo J. Tearney include Vanderbilt University Medical Center & Lahey Hospital & Medical Center.
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Papers
Comprehensive volumetric optical microscopy in vivo.
Seok Hyun Yun,Guillermo J. Tearney,Guillermo J. Tearney,Benjamin J. Vakoc,Milen Shishkov,Wang-Yuhl Oh,Adrien E. Desjardins,Adrien E. Desjardins,Melissa J. Suter,Raymond Chan,John A. Evans,Ik-Kyung Jang,Norman S. Nishioka,Norman S. Nishioka,Johannes F. de Boer,Johannes F. de Boer,Brett E. Bouma,Brett E. Bouma +17 more
TL;DR: The pilot study results suggest that this fiber-optic imaging technique termed optical frequency-domain imaging (OFDI) may be a useful clinical tool for comprehensive diagnostic imaging for epithelial disease and for evaluating coronary pathology and iatrogenic effects.
μOCT imaging using depth of focus extension by self-imaging wavefront division in a common-path fiber optic probe.
TL;DR: A supercontinuum-laser-based, μm-resolution OCT (μOCT) system and a 500μm-diameter, extended depth of focus single fiber optic probe for endoscopic and intravascular imaging were designed and fabricated and shown to be useful for achieving high-resolution, cross-sectional OCT imaging in catheter/endoscope-based medical imaging devices.
Imaging intracellular motion with dynamic micro-optical coherence tomography.
Hui Min Leung,Michelle L. Wang,Hany Osman,Elham Abouei,Calum MacAulay,Michele Follen,Joseph A. Gardecki,Guillermo J. Tearney +7 more
TL;DR: Depth-resolved d-µOCT images of intact tissue show that intracellular dynamics provides a new contrast mechanism for µOCT that highlights subcellular morphology and activity in epithelial surface maturation patterns.
Volumetric laser endomicroscopy in Barrett’s esophagus: interobserver agreement for interpretation of Barrett’s esophagus and associated neoplasia among high-frequency users
Arvind J. Trindade,Sumant Inamdar,Michael S. Smith,Kenneth J. Chang,Cadman L. Leggett,Charles J. Lightdale,Douglas K. Pleskow,Divyesh V. Sejpal,Guillermo J. Tearney,Rebecca M. Thomas,Michael B. Wallace +10 more
TL;DR: Volumetric laser endomicroscopy has a high level of agreement and accuracy among high-volume users and is a new imaging technique that allows for real time cross-sectional microstructure imaging that can detect BE neoplasia.
Aspergillus fumigatus Cell Wall Promotes Apical Airway Epithelial Recruitment of Human Neutrophils.
Michael Feldman,Richard A. Dutko,Michael A. Wood,Rebecca A Ward,Hui Min Leung,Ryan F. Snow,Denis De la Flor,Lael M. Yonker,Jennifer L. Reedy,Guillermo J. Tearney,Hongmei Mou,Bryan P. Hurley,Jatin M. Vyas +12 more
TL;DR: In inverted air-liquid interface cultures, it is demonstrated that the human airway epithelium responds to apical stimulation by A. fumigatus to promote the transepithelial migration of neutrophils from the basolateral membrane surface to the apical airway surface, providing critical insight into the initial epithelial host response to Aspergillus.