Guillermo J. Tearney
Harvard University
569 Papers
10.6K Citations
Guillermo J. Tearney is an academic researcher from Harvard University. The author has contributed to research in topics: Optical coherence tomography & Medicine. The author has an hindex of 114, co-authored 523 publications. Previous affiliations of Guillermo J. Tearney include Vanderbilt University Medical Center & Lahey Hospital & Medical Center.
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Papers
Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures
Andreas Wartak,Merle S. Schenk,Verena Bühler,Stefan Kassumeh,Reginald Birngruber,Guillermo J. Tearney +5 more
TL;DR: The highest resolution micrometer optical coherence tomography (µOCT) imaging of the morphologic micro-structure of excised swine and non-human primate corneas is demonstrated and polarization sensitive (PS) µOCT imaging is introduced, demonstrating, to the best of the authors' knowledge, the highest resolution corneal PS-OCT scans reported to date.
Heart wall velocimetry and exogenous contrast-based cardiac flow imaging in Drosophila melanogaster using Doppler optical coherence tomography
TL;DR: It is demonstrated that Doppler optical coherence tomography can quantify dynamic heart wall velocity and hemolymph flow in adult D. melanogaster and open up new possibilities for functional cardiovascular phenotyping of normal and mutant D.melanogaster.
Development of an airway mucus defect in the cystic fibrosis rat
Susan E. Birket,Joy M. Davis,Courtney M. Fernandez,Katherine L. Tuggle,Ashley M Oden,Kengyeh K. Chu,Guillermo J. Tearney,Guillermo J. Tearney,Michelle V. Fanucchi,Eric J. Sorscher,Steven M. Rowe +10 more
TL;DR: It is demonstrated that abnormal surface epithelium in CF does not cause delayed mucus transport in the absence of functional gland secretions, and abnormal bicarbonate transport represents a specific target for restoring mucus clearance, independent of effects on periciliary collapse.
Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR.
Susan E. Birket,Joy M. Davis,Courtney M. Fernandez-Petty,Alexander G Henderson,Ashley M Oden,Liping Tang,Hui Wen,Jeong S. Hong,Lianwu Fu,Andre Chambers,Alvin Fields,Gojun Zhao,Guillermo J. Tearney,Eric J. Sorscher,Steven M. Rowe +14 more
TL;DR: This humanized-CFTR rat expressing the G551D variant, obtained by zinc finger nuclease editing of a human cDNA super-exon, takes advantage of the endogenous rat promoter, resulting in appropriate expression compared to wild-type.
Excess mucus viscosity and airway dehydration impact COPD airway clearance
Vivian Y. Lin,Niroop Kaza,Susan E. Birket,Harrison Kim,Lloyd J. Edwards,Jennifer LaFontaine,Linbo Liu,Marina Mazur,Stephen A. Byzek,Justin Hanes,Guillermo J. Tearney,S. Vamsee Raju,Steven M. Rowe +12 more
TL;DR: Ferret mucus was hyperviscous following smoke exposure in vivo or in vitro, and contributed to diminished MCT, which persisted despite the absence of continued smoke exposure, elucidate the detrimental effects of cigarette smoke exposure on mucus clearance and suggest additional avenues for therapeutic intervention.