Guillermo J. Tearney
Harvard University
569 Papers
10.6K Citations
Guillermo J. Tearney is an academic researcher from Harvard University. The author has contributed to research in topics: Optical coherence tomography & Medicine. The author has an hindex of 114, co-authored 523 publications. Previous affiliations of Guillermo J. Tearney include Vanderbilt University Medical Center & Lahey Hospital & Medical Center.
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Papers
High-resolution optical coherence tomographic imaging using a mode-locked Ti:Al(2)O(3) laser source.
Brett E. Bouma,Guillermo J. Tearney,Stephen A. Boppart,Michael R. Hee,Mark E. Brezinski,James G. Fujimoto +5 more
TL;DR: A Kerr-lens mode-locked Ti:Al(2)O(3) oscillator, optimized for minimal coherence length, is demonstrated as a high-power source for high-resolution optical coherence tomographic imaging.
Atherosclerotic tissue characterization in vivo by optical coherence tomography attenuation imaging.
Gijs van Soest,Thadé P. M. Goderie,Evelyn Regar,Senada Koljenović,Geert L. J. H. van Leenders,Nieves Gonzalo,Sander van Noorden,Takayuki Okamura,Brett E. Bouma,Guillermo J. Tearney,J. Wolter Oosterhuis,Patrick W. Serruys,Anton F. W. van der Steen +12 more
TL;DR: This work presents a framework to enable systematic and automatic classification of atherosclerotic plaque constituents, based on the optical attenuation coefficient mu(t) of the tissue, and successfully applies the algorithm to OCT patient data.
Molecular Imaging of Fibrin Deposition in Deep Vein Thrombosis Using Fibrin-Targeted Near-Infrared Fluorescence
Tetsuya Hara,Brijesh Bhayana,Brian Thompson,Chase W. Kessinger,Ashok Khatri,Jason R. McCarthy,Ralph Weissleder,Charles P. Lin,Guillermo J. Tearney,Farouc A. Jaffer +9 more
TL;DR: The fibrin-targeted NIRF agent FTP11-Cy7 was shown to avidly and specifically bind human and murine thrombi, and enable sensitive, multimodal intravital and noninvasive N IRF molecular imaging detection of acute and subacute murine DVT in vivo.
Distribution of inflammation within carotid atherosclerotic plaques with high-risk morphological features: a comparison between positron emission tomography activity, plaque morphology, and histopathology.
Amparo L. Figueroa,Sharath Subramanian,Ricardo C. Cury,Quynh A. Truong,Joseph A. Gardecki,Guillermo J. Tearney,Udo Hoffmann,Thomas J. Brady,Ahmed Tawakol +8 more
TL;DR: The relationship between plaque inflammation and the number of HRM is not well understood as mentioned in this paper, however, it is known that plaque inflammation is associated with atherothrombosis.
The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke
S. Vamsee Raju,Vivian Y. Lin,Limbo Liu,Carmel M. McNicholas,Suman Karki,Peter A. Sloane,Liping Tang,Patricia L. Jackson,Wei Wang,Landon Wilson,Kevin Macon,Marina Mazur,John C. Kappes,Lawrence J. DeLucas,Stephen Barnes,Kevin L. Kirk,Guillermo J. Tearney,Steven M. Rowe +17 more
TL;DR: These effects of cigarette smoke on ion transport and the mucociliary transport apparatus are reversible by a CFTR potentiator in vitro, representing a potential therapeutic strategy in patients with chronic obstructive pulmonary disease with chronic bronchitis.