Guilhem Mascré

TL;DR: A dual role is identified for tumour-cell-derived V EGF in promoting cancer stemness: by stimulating angiogenesis in a paracrine manner, VEGF creates a perivascular niche for CSCs, and by directly affecting CSC’s through Nrp1 in an autocrine loop, VegF stimulatescancer stemness and renewal.

TL;DR: The cellular and molecular mechanisms that regulate wound healing in mouse tail epidermis are shown and, following wounding, progenitors divide more rapidly, but conserve their homoeostatic mode of division, leading to their rapid depletion, whereas SCs become active, giving rise to new progenitor that expand and repair the wound.

TL;DR: Lineage-tracing experiments show that the origin of specialized mechanosensory Merkel cells in the skin is epidermal progenitors, not the neural crest.

TL;DR: It is shown that multipotent hair-follicle-bulgeSCs have two important mechanisms for increasing their resistance to DNA-damage-induced cell death: higher expression of the anti-apoptotic gene Bcl-2 and transient stabilization of p53 after DNA damage in bulge SCs.