Guihua Wang
University of South China
6 Papers
20 Citations
Guihua Wang is an academic researcher from University of South China. The author has contributed to research in topics: Tumor necrosis factor alpha & p38 mitogen-activated protein kinases. The author has an hindex of 5, co-authored 6 publications.
Chat about Author
Papers
Polo-Like Kinase 1 (PLK1) Is Involved in Toll-like Receptor (TLR)-Mediated TNF-α Production in Monocytic THP-1 Cells
TL;DR: It is suggested that PLK1 is involved in TLR2- and TLR4-induced inflammation, and GW843682X may be valuable for the regulation of the inflammatory response.
Pro-Inflammatory Cytokine IL-1β Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma.
Yi Sun,Demao Zhu,Guihua Wang,Di Wang,Huashan Zhou,Xueting Liu,Manli Jiang,Lingjuan Liao,Zhiguang Zhou,Jinyue Hu +9 more
TL;DR: IL-1β and IL-1R1 promote cancer growth and metastasis by up-regulating CX CR4 expression and that CXCR4 may be a link between inflammation and cancer.
The activation of Toll-like receptor 4 reverses tumor differentiation in human glioma U251 cells via Notch pathway
Jinyue Hu,Bizhi Shi,Xueting Liu,Manli Jiang,Chuang Yuan,Binyuan Jiang,Yinghui Song,Yanhua Zeng,Guihua Wang +8 more
TL;DR: Results suggested that in human glioma U251 cells, TLR4 functions to reverse tumor differentiation, and it may be a target forglioma prevention and therapy.
19
A Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent Pathway
Yuchen Xia,Guihua Wang,Manli Jiang,Xueting Liu,Yan Zhao,Yinghui Song,Binyuan Jiang,Demao Zhu,Ling Hu,Zhao Zhang,Ting Cao,Ji Ming Wang,Jinyue Hu +12 more
TL;DR: In this article, the effect of GSR inhibition on the tumorigenicity of human cervical cancer is not fully understood, however, the authors have shown that GSR knockdown was achieved by RNA interference and showed that the cell death induced by 6-nitrobenzo[b]thiophene 1,1-dioxide (Stattic) also inhibited the enzymatic activity and induced the death of cervical cancer cells.
A20 Is Critical for the Induction of Pam3CSK4-Tolerance in Monocytic THP-1 Cells
TL;DR: It is reported that TLR1/2 ligand Pam3CSK4 induced tolerance in monocytic THP-1 cells, and pharmacologic inhibition of GSK3 signaling down-regulated A20 expression, up-regulated Pam3 CSK4-induced inflammatory responses, and partly reversed Pam3csK4 pre-treatment-induced tolerance, suggesting that G SKS3 is involved in TLR 1/2-inducedolerance by up-regulation of A20expression.