Guige Xu
Shandong Agricultural University
10 Papers
Guige Xu is an academic researcher from Shandong Agricultural University. The author has contributed to research in topics: Biology & Virus. The author has co-authored 1 publications.
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Papers
Isolation and characterization of a naturally attenuated novel duck reovirus strain as a live vaccine candidate.
TL;DR: Wang et al. as discussed by the authors investigated the biological characteristics and pathogenicity of the four NDRV strains and identified the N20 strain as a naturally attenuated strain, which is a promising live attenuated vaccine candidate against highly pathogenic DVR infection.
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Integrated miRNA and mRNA Expression Profiles Reveal Differentially Expressed miR-222a as an Antiviral Factor Against Duck Hepatitis A Virus Type 1 Infection
Nana Sui,Ruihua Zhang,Yue Jiang,Honglei Yu,Guige Xu,Jingyu Wang,Yanli Zhu,Zhijing Xie,Jiaqing Hu +8 more
TL;DR: The results reveal changes of mRNAs and miRNAs during DHAV-1 infection and suggest miR-222a as an antiviral factor against DHAv-1, indicating that miR–mRNA pairs with a negative correlation may be important for virus resistance, cell proliferation, and metabolism.
Duck hepatitis A virus type 1 transmission by exosomes establishes a productive infection in vivo and in vitro.
TL;DR: Wang et al. as discussed by the authors found that exosome-mediated DHAV-1 infection was resistant to antibody neutralization in vivo and in vitro, which might be an immune evasion mechanism of exosomes.
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Long Noncoding RNA Expression Rofiles Elucidate the Potential Roles of lncRNA- XR_003496198 in Duck Hepatitis A Virus Type 1 Infection
Nana Sui,Ruihua Zhang,Yue Jiang,Honglei Yu,Guige Xu,Jingyu Wang,Yanli Zhu,Zhijing Xie,Jiaqing Hu +8 more
TL;DR: This study comprehensively analyzed the lncRNA profiles upon DHAV-1 infection and screened the target genes involved in the innate immune response and autophagy signaling pathway, thereby revealing the essential roles of duck lncRNAs and broadening the understanding of host-virus interactions.
Nonstructural protein 2A2 from Duck hepatitis A virus type 1 inhibits interferon beta production by interaction with mitochondrial antiviral signaling protein and TANK-binding kinase 1.
Nana Sui,Ruihua Zhang,Yue Jiang,Honglei Yu,Guige Xu,Jingyu Wang,Yanli Zhu,Zhijing Xie,Jiaqing Hu +8 more
TL;DR: In this article , DHAV-1-encoded proteins were cloned and shown to strongly suppress IFN-β-luciferase activity, triggered by Sendai virus and polyriboinosinic polyribocytidylic acid [poly(I:C)], along with the transcription of IFNβ and downstream antiviral genes, including OASL, PKR, and TNF-a.
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