Guido Strada
20 Papers
119 Citations
Guido Strada is an academic researcher. The author has contributed to research in topics: Bladder cancer & Clear cell renal cell carcinoma. The author has an hindex of 10, co-authored 17 publications.
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Papers
The glucose and lipid metabolism reprogramming is grade-dependent in clear cell renal cell carcinoma primary cultures and is targetable to modulate cell viability and proliferation.
Cristina Bianchi,C Meregalli,Silvia Bombelli,Vitalba Di Stefano,Francesco Salerno,Barbara Torsello,Sofia De Marco,Giorgio Bovo,Ingrid Cifola,Eleonora Mangano,Cristina Battaglia,Guido Strada,Giuseppe Lucarelli,Robert H. Weiss,Roberto A. Perego +14 more
TL;DR: The data indicate that in ccRCC the Warburg effect is a grade-dependent feature, and fatty acid oxidation can be activated for different grade- dependent metabolic needs.
36-kDa Annexin A3 Isoform Negatively Modulates Lipid Storage in Clear Cell Renal Cell Carcinoma Cells
Silvia Bombelli,Barbara Torsello,Sofia De Marco,Giuseppe Lucarelli,Ingrid Cifola,C Grasselli,Guido Strada,Giorgio Bovo,Roberto A. Perego,Cristina Bianchi +9 more
TL;DR: The subcellular distribution of AnxA3 in the cellular endocytic compartment suggests its involvement in modulation of vesicular trafficking and might serve as a putative mechanism of lipid storage regulation in ccRCC cells, opening novel translational outcomes.
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The cross‐talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell Renal Cell Carcinoma cells
Sofia De Marco,Barbara Torsello,Emanuela Minutiello,I. Morabito,Chiara Grasselli,Silvia Bombelli,Nicolas Zucchini,Giuseppe Lucarelli,Guido Strada,Roberto A. Perego,Cristina Bianchi +10 more
TL;DR: The authors found that TGFβ1/Smad signalling is more activated in high versus low grade Renal Cell Carcinoma (ccRCC) and inversely correlates with Abl2 tyrosine kinase protein expression.
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Biological heterogeneity of putative bladder cancer stem-like cell populations from human bladder transitional cell carcinoma samples.
Angela Bentivegna,Donatella Conconi,Elena Panzeri,Elena Sala,Giorgio Bovo,P Viganò,Silvia Brunelli,Mario Bossi,Giovanni Tredici,Guido Strada,Leda Dalprà +10 more
TL;DR: The isolation and biological characterization of putative bladder CSC populations from primary TCCs indicated important karyotype changes and a positive selection for hypo‐ or near‐diploid cells, losing the complexity present in fresh tumors.
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Major Action of Endogenous Lysyl Oxidase in Clear Cell Renal Cell Carcinoma Progression and Collagen Stiffness Revealed by Primary Cell Cultures.
Vitalba Di Stefano,Barbara Torsello,Cristina Bianchi,Ingrid Cifola,Eleonora Mangano,Giorgio Bovo,Valeria Cassina,Sofia De Marco,Roberta Corti,C Meregalli,Silvia Bombelli,P Viganò,Cristina Battaglia,Cristina Battaglia,Guido Strada,Roberto A. Perego +15 more
TL;DR: It is found that endogenous LOX is overexpressed in ccRCC, is involved in a positive-regulative loop with HIF-1α, and has a major action onccRCC progression through cellular adhesion, migration, and collagen matrix stiffness increment; however, the oncosuppressive action of Lox-PP was not found to prevail.
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