Guglielmo Roma

TL;DR: The data suggest that transposon amplification may in part explain the increased size of the melon genome compared with the close relative cucumber, and a low number of nucleotide-binding site–leucine-rich repeat disease resistance genes were annotated, suggesting the existence of specific defense mechanisms in this species.

TL;DR: These findings reveal how single cells exposed to a uniform growth-promoting environment have the intrinsic ability to generate emergent, self-organized behaviour that results in the formation of complex multicellular asymmetric structures.

TL;DR: This resource identifies cellular targets for studying disease mechanisms in organoids and for targeted repair in human retinas and implicate unexpected cell types in diseases such as macular degeneration.

TL;DR: A potent, orally active, small-molecule enhancer of SMN2 splicing that elevates full-length SMN protein and extends survival in a severe SMA mouse model is described, demonstrating the feasibility of small molecule-mediated, sequence-selective splice modulation and the potential for leveraging this strategy in other splicing diseases.