Guenter Huhle
Heidelberg University
16 Papers
247 Citations
Guenter Huhle is an academic researcher from Heidelberg University. The author has contributed to research in topics: Natriuretic peptide & Chemokine. The author has an hindex of 11, co-authored 16 publications.
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Papers
Epidemiology of sepsis in Germany: results from a national prospective multicenter study
Christoph Engel,Frank M. Brunkhorst,Hans-Georg Bone,Reinhard Richard Brunkhorst,Herwig Gerlach,Stefan Grond,Matthias Gruendling,Guenter Huhle,Ulrich Jaschinski,Stefan John,Konstantin Mayer,Michael Oppert,Derk Olthoff,Michael Quintel,Max Ragaller,Rolf Rossaint,Frank Stüber,Norbert Weiler,Tobias Welte,Holger Bogatsch,Christiane S. Hartog,Markus Loeffler,Konrad Reinhart +22 more
TL;DR: The expected number of newly diagnosed cases with severe sepsis in Germany amounts to 76–110 per 100,000 adult inhabitants and future epidemiological studies should use standardized study methodologies with respect to sepsi definitions, hospital size, and daily and monthly variability.
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Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med
Christoph Engel,F. M. Brunkhorst,Hans-Georg Bone,Reinhard Brunkhorst,H. Gerlach,Stefan Grond,Matthias Gruendling,Guenter Huhle,Ulrich Jaschinski,Stefan John,Konstantin Mayer,Michael Oppert,Derk Olthoff,Michael Quintel,Max Ragaller,Rolf Rossaint,Frank Stüber,Norbert Weiler,Tobias Welte,Holger Bogatsch,Christiane S. Hartog,Markus Loeffler,Konrad Reinhart +22 more
- 01 Jan 2007
TL;DR: In this article, a 1-day point-prevalence study was conducted to determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size.
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Activated protein C inhibits the release of macrophage inflammatory protein-1-alpha from THP-1 cells and from human monocytes
Martina Brueckmann,Ursula Hoffmann,Lothar de Rossi,Hans Martin Weiler,Volker Liebe,Siegfried Lang,Jens J. Kaden,Martin Borggrefe,Karl K. Haase,Guenter Huhle +9 more
TL;DR: The ability of APC to decrease the release of the C-C chemokine MIP-1-alpha from the monocytic cell line THP-1 and from human monocytes may identify a novel immunomodulatory pathway by which APC exerts its anti-inflammatory action and may contribute to control the inflammatory response in sepsis.
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Recombinant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of protease-activated receptor-1.
Martina Brueckmann,Sarah Horn,Siegfried Lang,Kenji Fukudome,Adriane Schulze Nahrup,Ursula Hoffmann,Jens J. Kaden,Martin Borggrefe,Karl K. Haase,Guenter Huhle +9 more
TL;DR: Results demonstrate that induction of COX-2-expression is an important response of HUVEC to stimulation with rhAPC and may represent a new molecular mechanism, by whichrhAPC promotes upregulation of prostanoid production in human endothelium.
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Stabilization of monocyte chemoattractant protein-1-mRNA by activated protein C.
Martina Brueckmann,Antje Marx,Hans Martin Weiler,Volker Liebe,Siegfried Lang,Jens J. Kaden,Wolfgang Zieger,Martin Borggrefe,Guenter Huhle,Karl K. Haase +9 more
TL;DR: The ability of APC to upregulate the production of MCP-1, most likely by increasing the stability of M CP-1-mRNA rather than by transcriptional activation via NF-B, identifies a novel immunomodulatory pathway, by which APC may control the local inflammatory reaction, thereby initiating wound repair and modulating the extent of endothelial injury.
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