Gudrun Scherer
University of Kiel
10 Papers
57 Citations
Gudrun Scherer is an academic researcher from University of Kiel. The author has contributed to research in topics: Apoptosis & Caspase. The author has an hindex of 9, co-authored 10 publications.
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Papers
Sensitization to death receptor cytotoxicity by inhibition of fas-associated death domain protein (FADD)/caspase signaling. Requirement of cell cycle progression.
TL;DR: It is reported that in NIH3T3 cells, apoptosis in response TNF and cycloheximide is not inhibited by the broad spectrum caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone (zVAD.fmk).
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Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-κB, elicits caspase activity, and enhances cytotoxicity
TL;DR: It is demonstrated that pharmacological inhibition of p38 MAPK enhances TNF-induced cell death in murine fibroblast cell lines L929 and NIH3T3 and that the nuclear factor kappaB (NF-kappaB)-dependent gene expression was reduced by p38MAPK inhibition.
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Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes.
Maren Paulsen,Sandra Ussat,Marten Jakob,Gudrun Scherer,Inga Lepenies,Stefan Schütze,Dieter Kabelitz,Sabine Adam-Klages +7 more
TL;DR: It is provided evidence that during T cell proliferation the intracellular caspase inhibitor X‐linked inhibitor‐of‐apoptosis protein (XIAP) interacts with caspases‐3/‐7, thereby blocking their full activation, substrate cleavage, and cell death.
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Caspase 7-induced cleavage of kinectin in apoptotic cells
TL;DR: Kinectin has been characterized as the first known receptor for the molecular motor kinesin, which is critically involved in microtubule‐based vesicle transport and membrane trafficking, and is identified as a target for caspase‐mediated proteolysis during apoptosis.
32
Upregulation of p21WAF1/Cip1 precedes tumor necrosis factor-induced necrosis-like cell death ☆
Sandra Ussat,Ulf-Eike Werner,Marie-Luise Kruse,Silke Lüschen,Gudrun Scherer,Dieter Kabelitz,Sabine Adam-Klages +6 more
TL;DR: It is reported that tumor necrosis factor-induced necrotic death is preceded by an upregulation of the cyclin-dependent kinase inhibitor p21(WAF1/Cip1) and an important role of cell cycle progression for this sensitization effect is identified.
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