Guangyan Yan
Sichuan University
11 Papers
1 Citations
Guangyan Yan is an academic researcher from Sichuan University. The author has contributed to research in topics: Taurine & Creatine. The author has an hindex of 10, co-authored 11 publications.
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Papers
NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration
Qian Bu,Guangyan Yan,Pengchi Deng,Feng Peng,Hongjun Lin,Youzhi Xu,Zhixing Cao,Tian Zhou,Aiqin Xue,Yanli Wang,Xiaobo Cen,Yinglan Zhao +11 more
TL;DR: Findings indicate that disturbances in energy and amino acid metabolism and the gut microflora environment may be attributable to the slight injury to the liver and heart caused by TiO(2) NPs.
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Zinc oxide nanoparticles cause nephrotoxicity and kidney metabolism alterations in rats
Guangyan Yan,Yina Huang,Qian Bu,Lei Lv,Pengchi Deng,Jiaqing Zhou,Yanli Wang,Yanzhu Yang,Qiangqiang Liu,Xiaobo Cen,Yinglan Zhao +10 more
TL;DR: Findings show that zinc oxide NPs can disturb the energy metabolism and cause mitochondria and cell membrane impairment in rat kidney, which may contribute to ZnO NPs-induced nephrotoxicity.
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Protective Role of Taurine Against Morphine-Induced Neurotoxicity in C6 Cells via Inhibition of Oxidative Stress
Jiaqing Zhou,Yan Li,Guangyan Yan,Qian Bu,Lei Lv,Yanzhu Yang,Jinxuan Zhao,Xue Shao,Yi Deng,Ruimin Zhu,Yinglan Zhao,Xiaobo Cen +11 more
TL;DR: The results show that taurine possesses the capability to ameliorate morphine-induced oxidative insult and apoptosis in C6 cells, probably due to its antioxidant activity rather than activation of GABA receptors.
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Proteomic analysis of the nucleus accumbens in rhesus monkeys of morphine dependence and withdrawal intervention
Qian Bu,Yanzhu Yang,Guangyan Yan,Zhengtao Hu,Chunyan Hu,Jiachuan Duan,Lei Lv,Jiaqing Zhou,Jinxuan Zhao,Xue Shao,Yi Deng,Yan Li,Hongyu Li,Ruiming Zhu,Yinglan Zhao,Xiaobo Cen +15 more
TL;DR: A comprehensive understanding of the neuropathophysiology associated with morphine addiction and withdrawal therapy in primate is provided, which is helpful for the development of opiate withdrawal pharmacotherapies.
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1H NMR-based metabonomic analysis of brain in rats of morphine dependence and withdrawal intervention
Zhengtao Hu,Yi Deng,Chunyan Hu,Pengchi Deng,Qian Bu,Guangyan Yan,Jiaqing Zhou,Xue Shao,Jinxuan Zhao,Yan Li,Ruiming Zhu,Youzhi Xu,Yinglan Zhao,Xiaobo Cen +13 more
TL;DR: Interestingly, morphine-induced changes in lactic acid, creatine and NAA were clearly reversed by intervention of methadone or clonidine, which indicates the profound disturbances of energy metabolism, amino acid metabolism and neurotransmitters caused by chronic morphine treatment.
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