GuangJun Zhang
Purdue University
38 Papers
287 Citations
GuangJun Zhang is an academic researcher from Purdue University. The author has contributed to research in topics: Zebrafish & Gene. The author has an hindex of 17, co-authored 36 publications. Previous affiliations of GuangJun Zhang include Massachusetts Institute of Technology & University of Florida.
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Papers
Correction: Corrigendum: KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors
TL;DR: KANK1 inhibits cell growth by inducing apoptosis though regulating CXXC5 in human malignant peripheral nerve sheath tumors via KANK1-dependent cell reprograming.
AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma.
Yen-Hsing Li,Jia Luo,Yung-Yi C. Mosley,Victoria Hedrick,Lake N. Paul,Julia Chang,GuangJun Zhang,Yu-Kuo Wang,Max R. Banko,Anne Brunet,Shihuan Kuang,Jen-Leih Wu,Chun Ju Chang,Matthew P. Scott,Jer Yen Yang +14 more
TL;DR: The Hedgehog (Hh) pathway regulates cell differentiation and proliferation during development by controlling the Gli transcription factors and AMP-activated protein kinase (AMPK) reduces GLI1 protein levels and stability, thus blocking Sonic-hedgehog-induced transcriptional activity.
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Genome duplication and the origin of the vertebrate skeleton.
GuangJun Zhang,Martin J. Cohn +1 more
TL;DR: During vertebrate embryonic development, tissue patterning and differentiation are regulated by members of multigene families, and understanding the natural histories of gene families involved in skeletogenesis is central to the issue of vertebrate skeletal evolution.
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Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism
Marco Lezzerini,Marianna Penzo,Marie-Françoise O'Donohue,Carolina Marques dos Santos Vieira,Manon Saby,Hyung L. Elfrink,Illja J. Diets,Anne-Marie Hesse,Yohann Couté,Marc Gastou,Marc Gastou,Alexandra Nin-Velez,Peter G. J. Nikkels,Alexandra N. Olson,Evelien Zonneveld-Huijssoon,Evelien Zonneveld-Huijssoon,Marjolijn C.J. Jongmans,Marjolijn C.J. Jongmans,GuangJun Zhang,Michel van Weeghel,Riekelt H. Houtkooper,Marcin W. Wlodarski,Roland P. Kuiper,Marc Bierings,Jutte van der Werff ten Bosch,Thierry Leblanc,Lorenzo Montanaro,Jonathan D. Dinman,Lydie Da Costa,Pierre-Emmanuel Gleizes,Alyson W. MacInnes +30 more
TL;DR: It is indicated that variants in the same RP gene can drive similar ribosome biogenesis defects yet still have markedly different downstream consequences and clinical impacts.
Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers
GuangJun Zhang,Sebastian Hoersch,Adam Amsterdam,Charles Whittaker,Jacqueline A. Lees,Nancy Hopkins +5 more
TL;DR: It is reported that malignant peripheral nerve sheath tumors (MPNSTs) that arise in zebrafish as a result of mutations in either ribosomal protein (rp) genes or in p53 are highly aneuploid.
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