Guan-Jun Yang
University of Macau
60 Papers
102 Citations
Guan-Jun Yang is an academic researcher from University of Macau. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 33 publications. Previous affiliations of Guan-Jun Yang include Ningbo University.
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Papers
A small molecule HIF-1α stabilizer that accelerates diabetic wound healing.
Guodong Li,Chung-Nga Ko,Dan Li,Chao Yang,Wanhe Wang,Guan-Jun Yang,Carmelo Di Primo,Carmelo Di Primo,Vincent Kam Wai Wong,Yaozu Xiang,Ligen Lin,Dik-Lung Ma,Chung-Hang Leung +12 more
TL;DR: In this paper, a cyclometalated iridium(III) metal complex (1a) was used as a stabilizer of hypoxia-inducible factor 1α (HIF-1α).
Pharmacological Inhibition of LSD1 for Cancer Treatment.
TL;DR: This review will present the structural aspects of LSD1, its role in carcinogenesis, a comparison of currently available approaches for screening LSD1 inhibitors, a classification of LSD 1 inhibitors, and its potential as a drug target in cancer therapy.
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The emerging role of KDM5A in human cancer
Guan-Jun Yang,Ming-Hui Zhu,Xin-Jiang Lu,Yan-Jun Liu,Jian-Fei Lu,Chung-Hang Leung,Dik-Lung Ma,Jiong Chen +7 more
TL;DR: A review of the role of Lysine-specific demethylase 5A (KDM5A) in human cancers is presented in this paper, where the authors summarize the roles of KDM5a and survey the field of inhibitors.
The design and development of covalent protein-protein interaction inhibitors for cancer treatment.
TL;DR: This review will highlight the design and development of therapeutic agents targeting PPIs for cancer therapy and suggest that there is a reduced risk for the development of drug resistance against covalent drugs, which is a major challenge in areas such as oncology and infectious diseases.
The application of a G-quadruplex based assay with an iridium(iii) complex to arsenic ion detection and its utilization in a microfluidic chip
Sheng Lin,Wanhe Wang,Chong Hu,Guan-Jun Yang,Chung-Nga Ko,Kangning Ren,Chung-Hang Leung,Dik-Lung Ma +7 more
TL;DR: The iridium(iii) complex 1 was synthesized and employed in constructing an assay which is based on a G-quadruplex for detecting arsenic ions in aqueous solution and showed high selectivity towards arsenic ions over other metal ions.
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