The invention relates to a sustained release injection preparation and a preparation method and application of the preparation Specifically, the invention relates to a sustained release injection preparation, which comprises a psychotropic medication and a nonaqueous carrier and can be released in a sustained manner within at least one week The sustained release injection preparation of the invention has the advantages of better sustained release effect, longer effect, better stability, simple dosage form, no need of lyophilization, eaier preparation process, lower cost, and more convenience for use

Sustained release injection preparation and preparation method and application thereof

The invention discloses a method for detecting tetracycline by the utilization of a nano-microsphere time-resolved fluorescent probe, comprising the following steps: preparing carboxylic polystyrene nano-microspheres and preparing nano-fluorescent microspheres, wherein molar ratio of rare earth ions to a beta-diketone chelate to a fluorescence enhancement synergist is 1:3:3-1:3:4; preparing a nano-microsphere time-resolved fluorescent-tetracycline probe, preparing a chromatographic test strip, and detecting tetracycline by the utilization of the above probe and the chromatographic test strip.The detection method has high detection sensitivity and wide detection range, is stable and reliable, and has a good commercial application prospect.

Method for detecting aflatoxin M1 by utilization of nano-microsphere time-resolved fluorescent probe

The invention discloses a method for detecting sulbactam in milk. The method comprises steps as follows: (1), antibiotics in an antibiotic positive control group, a beta-lactamase positive control group and a sample group are detected respectively, wherein the antibiotic positive control group is prepared from the antibiotics and milk without the antibiotics, beta-lactamase and sulbactam through mixing, the beta-lactamase positive control group is prepared from the antibiotics, the beta-lactamase and the milk without the antibiotics, the beta-lactamase and the sulbactam through mixing, and the sample group is prepared from to-be-detected milk, the antibiotics and the beta-lactamase through mixing; (2), the sulbactam in the to-be-detected milk is qualitatively determined on the basis of a detection result. According to the method, the sulbactam in the milk can be detected accurately, and the operation is simple and convenient.

Method for detecting sulbactam in milk

The invention relates to a long-acting ceftiofur hydrochloride injection The injection is prepared by a method comprising the following steps: adding a ceftiofur hydrochloride ethanol solution into an ethyl beta-cyclodextrin saturated aqueous solution, stirring and including; filtering and sterilizing through a 022mu m milliporous filter membrane; performing spray drying to prepare a ceftiofur hydrochloride inclusion; adding a suspending agent, a dispersing agent and a stabilizing agent into partial injection solvent, dissolving at 100 DEG C, and adding the injection solvent to the whole amount, and performing dry heat sterilization at 150 DEG C for 1 hour; cooling the dispersion liquid to room temperature, adding the ceftiofur hydrochloride inclusion into the dispersion liquid, and uniformly stirring; adding the sterilized injection water, and uniformly stirring to obtain a mixed solution; preparing the long-acting ceftiofur hydrochloride injection by a high-speed shearing dispersion machine The preparation process is simple in operation; the prepared suspension injection has the advantages of uniform granularity, good fluidity, slow settlement, good redispersion property, wall adhesion prevention of liquid medicine, good nozzle cleaning performance, no discoloration after long-term storage and stable chemical property After the preparation is injected to a pig in an intramuscular manner, the preparation is released slowly, long in elimination half life, and smooth in plasma drug concentration, can be used for prolonging the effective acting period of the medicine in a body and reducing the number of administration times, and is convenient to use

Long-acting ceftiofur hydrochloride injection and preparation method thereof

The invention discloses a preparation method of a long-acting hydrochloric ceftiofur injection. The preparation method is characterized by including: using soybean oil as a solvent, heating the soybean oil to 140-150 DEG C, holding the temperature for 60min for sterilizing, and cooling to room temperature; dissolving or dispersing 0.5-2.0wt% of and 0.5-1.5wt% of according to prescription amounts in 70-80% of the sterilized solvent; guiding into a colloid mill for grinding, adding 10.2-10.8wt% of hydrochloric ceftiofur according to a prescription amount after grinding is finished, adopting a mode of alternating circulating grinding and non-circulating grinding for grinding, checking whether particle fineness reaches 2.5-5.0um or not, stopping grinding after requirements are met, and adding the sterilized solvent to the prescription amount to obtain an intermediate product; testing ceftiofur content and product character of the intermediate product, after passing needle drawing experiment, filling, externally packing, warehousing, and obtaining the injection after passing tests of content, sterility, granularity and related matter. Results show that when consumption of and is 1%, production process and product quality of the injection are stable.

Preparation method of long-acting hydrochloric ceftiofur injection

The invention belongs to the field of food detection and in particular relates to a kit for quantitatively detecting beta-lactamase residue in milk. The kit for quantitatively detecting beta-lactamase residue in milk is characterized in that the kit comprises an elisa plate enveloped with penicillin-binding proteins, marker coupled beta-lactam antibiotics, a skim milk powder freeze dried product of which the substrate reference 1 is beta-lactam antibiotics and which has the concentration of 0ppb, a skim milk powder freeze dried product of which the substrate reference 2 is beta-lactam antibiotics containing calibration concentration, and a beta-lactam antibiotic standard substance. The kit has high specificity and sensitivity, beta-lactam with the concentration of about 0.5U/ml can be detected, and the linear detection range is 1-16 U/ml; intra-batch CV percent of the kit is less than 10 percent, the inter-batch CV percent is less than 20 percent, and high precision is reflected; the detection steps are simple, the time consumption is low, and the cost is low; according to the kit, the beta-lactamase residue can be accurately, quantitatively and rapidly detected at high throughput, and the requirements of enterprises and detection mechanisms are met.

Kit for quantitatively detecting beta-lactamase residue in milk

The invention discloses a long-acting ceftiofur hydrochloride injection and a preparation method thereof. The long-acting ceftiofur hydrochloride injection of the invention is prepared from the following raw materials in percentage by weight: 10.2%-10.8% of ceftiofur hydrochloride, 2.0%-6.5% of additive and balance of soybean oil for injection. The long-acting ceftiofur hydrochloride injection of the invention can slowly release drug effect; the duration time of the blood drug concentration of the long-acting ceftiofur hydrochloride injection is 72-84 hours, which is greatly longer than the duration time of the blood drug concentration of the current ceftiofur hydrochloride injection; and compared with the conventional injection which needs to be injected once per day, the long-acting ceftiofur hydrochloride injection only needs to be injected once every 3 days and has good stability.

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Kit for quantitatively detecting beta-lactamase residue in milk

Long-acting ceftiofur hydrochloride injection and preparation method thereof