The invention relates to a novel controlled release pellet preparation and its preparation method, and especially relates to a tamsulosin hydrochloride controlled release pellet preparation and its preparation method. The controlled release pellet adopts a drug-loaded controlled release layer to coat a blank pellet and an enteric coating to coat the drug-loaded controlled release layer in order to control the drug release, the drug release can be realized in an acidic or weakly alkaline environment, and good absorption is realized when the pellet enters a body. The pellet has the advantages of good release degree homogeneity, simple preparation technology and good repeatability. The invention further provides a novel drug controlled release pellet suitable for small-dimension drugs. The novel drug controlled release pellet still well controls the drug release when the drug load amount reduces to 10% or less of a total weight.

Controlled release pellet preparation and its preparation method

The invention discloses a stable enteric lansoprazole capsule prepared through a nanometer technology, and a preparation method thereof The capsule is composed of the following components, by weight, 10 part of lansoprazole (having a raw material particle size of 400-500nm), 067-30 parts of mannitol, 067-20 parts of talcum powder, 01-03 parts of starch, 003-01 parts of disodium hydrogen phosphate, 003-01 parts of hydroxypropyl methyl cellulose, 10-15 parts of polyvinylpyrrolidone K, 60-90 parts of 95% ethanol, 20-30 parts of acrylic resin II, 008-012 parts of diethyl phthalate and 003-005 parts of polysorbate 80 In the above preparation, mannitol and the talcum powder are used as diluents, and disodium hydrogen phosphate is used as a pH value adjusting agent to make the core of a pellet alkaline and improve the stability of lansoprazole; and the quality of the enteric lansoprazole pellet capsule prepared through adopting the preparation method is reliable, and reaches English BP standards

Stable enteric lansoprazole capsule and preparation method thereof

The invention discloses a tamsulosin hydrochloride sustained-release pellet preparation. The tamsulosin hydrochloride sustained-release pellet preparation comprises a tamsulosin hydrochloride sustained-release pellet core, a sustained-release coating layer, and an enteric soluble coating layer; and is a capsule preparation. Three slow release methods including skeleton slow-release, membrane control slow-release, and enteric coating are adopted for preparation of the tamsulosin hydrochloride sustained-release pellet preparation; the obtained tamsulosin hydrochloride sustained-release pellet capsule preparation is capable of controlling releasing from the stomach to the intestine, so that adverse reaction caused by large amount absorption of tamsulosin hydrochloride in a short time is prevented. A preparation method of the tamsulosin hydrochloride sustained-release pellet preparation is simple; and in vivo release of tamsulosin hydrochloride can be controlled stably and effectively.

Tamsulosin hydrochloride sustained-release pellet preparation

An acid-unstable, insoluble lansoprazole-containing oral formulation, and a method of preparing the same are provided. The lansoprazole-containing oral formulation is resistant to activity loss caused by gastric juice, has improved dissolution characteristics, and thus ensures effective delivery of lansoprazole into the body through oral administration.

Oral formulation comprising lansoprazole and the preparation method thereof

The invention provides a tamsulosin sustained-release pellet, and the drug release of the sustained-release pellet is controlled through a blank pellet core coated with a drug-loaded sustained-release layer and then coated with an enteric coating, and the drug can be both released in an acidic or weak alkaline environment and is absorbed well in vivo. Also, release homogeneity is good, preparation technology is simple and repeatability is good.

Tamsulosin sustained-release pellet preparation and preparation method thereof

The invention discloses tamsulosin hydrochloride sustained-release pellets, which are prepared by coating medicament-containing blank pellets, wherein the blank pellets contain microcrystalline cellulose, soluble starch, lactose and croscarmellose sodium. Two layers of coating liquid are a Surelease sustained-release coating material and an enteric-coating material Kolicoat MAE 30DP respectively and the tamsulosin hydrochloride sustained-release pellets are capsules. The tamsulosin hydrochloride sustained-release pellets of the invention adopt the sustained-release coating material and the enteric-coating material to control the release of medicaments. The prepared tamsulosin hydrochloride sustained-release pellet capsules release less than 40 percent of medicaments in hydrochloric acid solution with a pH value of 1.2 in two hours and release 40 to 70 percent (about 60 percent) of medicaments in phosphate buffer solution with a pH value of 6.8 in three hours and over 70 percent (about 90 percent) of medicaments in five hours, so the prepared tamsulosin hydrochloride sustained-release pellet capsules meet the requirements of quality standards. The invention discloses a preparation method of the tamsulosin hydrochloride sustained-release pellets.

Tamsulosin hydrochloride sustained-release pellets and preparation method thereof

The invention discloses a Lansoprazole enteric pellet with improved stability and in-vitro release and a preparation method thereof. The Lansoprazole enteric pellet comprises the following components in parts by weight: 1-5 parts of acidifying or alkalizing agent, 80-200 parts of water, 2-8 parts of binder, 15-30 parts of Lansoprazole, a defined amount of defoamer, 0.5-5 parts of solubilizer, 50-200 parts of Celphere, and the balance of contagion gown and enteric coating. According to the invention, the technical problems of low dose, low release in buffer solutions, unstable medicine storage and the like are solved.

Lansoprazole enteric pellet and preparation method thereof

The invention discloses a preparation method of a propofol medium/long-chain fat emulsion injection. The method comprises the following steps: dissolving glycerin and sodium hydroxide in water for injection under nitrogen protection, and controlling the temperature of a water phase at 50 to 80 DEG C; under the protection of nitrogen, propofol, oleic acid, egg yolk lecithin are dissolved in soybeanoil and medium-chain triglyceride, an oil phase is heated to 50-80 DEG C, and the material is stirred to dissolve; under the protection of nitrogen, the oil phase and the water phase are mixed in a weight ratio of 1:4 to 6, and the colostrum is obtained by shearing; the colostrum is homogenized by 5 to 20 bar homogenization pressure for one time, is homogenized by the 200 bar homogenization pressure for one time, and is homogenized by the 400 bar homogenization pressure for 7 times to obtain the final milk; the final milk is filtered through a 1 [mu]m filter core; a glass infusion bottle or ampoule is filled with the final milk, the material is sterilized at 121 DEG C for 10 min, and cooled to room temperature. The preparation method of the invention avoids local over-alkali of the emulsion, has better stability and safety, and has remarkable commercial production feasibility.

Preparation method of propofol medium/long-chain fat emulsion injection

Disclosed is a method for preparing a propofol medium/long chain fat emulsion injection, the preparation method comprising: under the protection of nitrogen, dissolving glycerin and sodium hydroxide in water for injection, and controlling the aqueous phase temperature at 50oC-80oC; and under the protection of nitrogen, dissolving propofol, oleic acid and egg yolk lecithin in an soybean oil and a medium chain triglyceride, heating the oil phase to 50oC-80oC, shearing and stirring, and mixing the aqueous phase and the oil phase, shearing same to prepare a primary emulsion, and homogenizing the primary emulsion to obtain a final emulsion. A propofol medium/long chain fat emulsion injection prepared by the method is also disclosed.

Method for preparing propofol medium/long chain fat emulsion injection

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Tamsulosin hydrochloride sustained-release pellets and preparation method thereof

Lansoprazole enteric pellet and preparation method thereof

Preparation method of propofol medium/long-chain fat emulsion injection

Method for preparing propofol medium/long chain fat emulsion injection