Gregory Mellier
National University of Singapore
6 Papers
50 Citations
Gregory Mellier is an academic researcher from National University of Singapore. The author has contributed to research in topics: Cancer cell & Heat shock protein. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Gregory Mellier include Claude Bernard University Lyon 1 & University of Lyon.
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Papers
TRAILing death in cancer.
TL;DR: An overview of the biology, function and translational relevance of TRAIL is presented with a specific view to discussing the various regulatory mechanisms and the current trends in reverting TRAIL resistance of cancer cells with the obvious implication of an improved clinical outcome.
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The three Rs along the TRAIL: resistance, re-sensitization and reactive oxygen species (ROS).
Gregory Mellier,Shazib Pervaiz +1 more
TL;DR: The basic biology of TRAIL signalling in cancer cells is reviewed, the mechanisms underlying resistance to TRAIL are highlighted and the ability of small molecule compounds to re-sensitize cells to TRAil-mediated apoptosis is highlighted.
24
Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27
TL;DR: A novel mechanism of small molecule sensitization to TRAIL through targeting of Hsp27 functions, rather than its overall expression, leading to decreased cellular protection, which could have therapeutic implications for overcoming chemotherapy resistance in tumor cells.
Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP
TL;DR: Computational modelling extracted novel biological implications from measured dynamics, identified time intervals with unexplained effects, and clarified the non-monotonic effects of the drug LY30 on cFLIP during cancer cell apoptosis.
Cytotoxic effects induced by oxidative stress in cultured mammalian cells and protection provided by Hsp27 expression
André-Patrick Arrigo,Wance Firdaus,Gregory Mellier,Maryline Moulin,Catherine Paul,Chantal Diaz-Latoud,Carole Kretz-Remy +6 more
TL;DR: In this article, the effects of oxidative stress on the oxidation of macromolecules have been studied in mammalian cells and the protection of a small heat shock protein against the deleterious effects induced by oxidative stress.