Gregory M. I. Redpath
University of New South Wales
20 Papers
7 Citations
Gregory M. I. Redpath is an academic researcher from University of New South Wales. The author has contributed to research in topics: Endosome & Endocytic cycle. The author has an hindex of 7, co-authored 10 publications. Previous affiliations of Gregory M. I. Redpath include University of Otago & University of Sydney.
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Papers
A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation.
Ewoud B. Compeer,Ewoud B. Compeer,Felix Kraus,Felix Kraus,Manuela Ecker,Gregory M. I. Redpath,Mayan Amiezer,Mayan Amiezer,Nils Rother,Nils Rother,Philip R. Nicovich,Natasha Kapoor-Kaushik,Qiji Deng,Guerric P. B. Samson,Zhengmin Yang,Jieqiong Lou,Michael Carnell,Haig Vartoukian,Katharina Gaus,Jérémie Rossy,Jérémie Rossy +20 more
TL;DR: It is shown that a mobile endocytic network connects clathrin-independent receptor endocytosis to recycling which is required for T cell activation, and that flotillins are essential for Tcell activation, supporting TCR nanoscale organization and signaling.
Membrane Heterogeneity Controls Cellular Endocytic Trafficking
Gregory M. I. Redpath,Gregory M. I. Redpath,Verena M. Betzler,Verena M. Betzler,Pascal Rossatti,Pascal Rossatti,Jérémie Rossy +6 more
TL;DR: Accumulating evidence leads us to believe that the trafficking fate of internalized proteins is sealed following endocytosis, as this distinct membrane identity is preserved through theendocytic pathway, upon fusion of endocytic vesicles with early and sorting endosomes.
Flotillins promote T cell receptor sorting through a fast Rab5-Rab11 endocytic recycling axis.
Gregory M. I. Redpath,Manuela Ecker,Natasha Kapoor-Kaushik,Haig Vartoukian,Michael Carnell,Daryan Kempe,Maté Biro,Nicholas Ariotti,Jérémie Rossy,Jérémie Rossy +9 more
TL;DR: It is shown that the flotillin membrane proteins may regulate the transfer of internalized T cell receptors into Rab5 and Rab11-positive endosomes to support its rapid recycling.
Serotonin Receptor and Transporter Endocytosis Is an Important Factor in the Cellular Basis of Depression and Anxiety
Nikita Deo,Gregory M. I. Redpath +1 more
TL;DR: How a thorough understanding of 5-HT receptor and SERT endocytosis is integral to understanding the biological basis of depression and anxiety is highlighted and to facilitate the development of a next generation of specific, efficacious antidepressant treatments is proposed.
Endosomal sorting sorted - motors, adaptors and lessons from in vitro and cellular studies.
TL;DR: In this article , the authors focus on how motors and their cargo adaptors regulate positioning of cargoes from the earliest stages of endocytosis and through the two main intracellular itineraries: degradation at the lysosome or recycling back to the plasma membrane.
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