Gregory J. Hannon
University of Cambridge
438 Papers
4.9K Citations
Gregory J. Hannon is an academic researcher from University of Cambridge. The author has contributed to research in topics: RNA interference & Biology. The author has an hindex of 165, co-authored 421 publications. Previous affiliations of Gregory J. Hannon include Case Western Reserve University & Federal University of Rio de Janeiro.
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Papers
Genome and transcriptome of the regeneration-competent flatworm, Macrostomum lignano
Kaja A. Wasik,James Gurtowski,Xin Zhou,Xin Zhou,Olivia Mendivil Ramos,M. Joaquina Delás,M. Joaquina Delás,Giorgia Battistoni,Giorgia Battistoni,Osama El Demerdash,Ilaria Falciatori,Ilaria Falciatori,Dita B. Vizoso,Andrew D. Smith,Peter Ladurner,Lukas Schärer,W. Richard McCombie,Gregory J. Hannon,Gregory J. Hannon,Michael C. Schatz +19 more
TL;DR: The genome and transcriptome assemblies for Macrostomum lignano, a free-living flatworm that can regenerate nearly its entire body following injury, are presented and gene-expression patterns during regeneration are probed, examining pathways important to stem cell function.
Silencing of microRNA families by seed-targeting tiny LNAs.
Susanna Obad,Camila O. dos Santos,Andreas Petri,Markus Heidenblad,Oliver Broom,Cristian I. Ruse,Cexiong Fu,Morten Lindow,Jan Stenvang,Ellen Marie Straarup,Henrik Frydenlund Hansen,Troels Koch,Darryl J. Pappin,Gregory J. Hannon,Sakari Kauppinen,Sakari Kauppinen +15 more
TL;DR: A method that enables antagonism of miRNA function using seed-targeting 8-mer locked nucleic acid (LNA) oligonucleotides, termed tiny LNAs is developed, which supports the utility of tinyLNAs in elucidating the functions of mi RNA families in vivo.
Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).
Douglas J. Demetrick,S. Matsumoto,Gregory J. Hannon,K. Okamoto,Yue Xiong,Hui Zhang,David Beach +6 more
TL;DR: The chromosomal mapping by FISH of the genes for several cdk-associated proteins including human CCNC to 6q21, CCNE to 19q12-->q13, CDKN1 (p21) to 6p21.2 and CDKN3 (KAP to 14q22) is described.
The Structure of Human Argonaute-2 in Complex with miR-20a
Elad Elkayam,Claus-D. Kuhn,Claus-D. Kuhn,Ante Tocilj,Ante Tocilj,Astrid D. Haase,Emily M. Greene,Emily M. Greene,Emily M. Greene,Gregory J. Hannon,Gregory J. Hannon,Leemor Joshua-Tor,Leemor Joshua-Tor,Leemor Joshua-Tor +13 more
TL;DR: Interestingly, miRNA binding confers remarkable stability on hAgo2, locking this otherwise flexible enzyme into a stable conformation, at 2.2 Å resolution.
miR-19 is a key oncogenic component of mir-17-92
Virginie Olive,Margaux J Bennett,James C. Walker,Cong Ma,Iris Jiang,Carlos Cordon-Cardo,Qi-Jing Li,Scott W. Lowe,Gregory J. Hannon,Lin He +9 more
TL;DR: The essential role of miR-19 is identified as the key oncogenic component of mir-17-92, both necessary and sufficient for promoting c-myc-induced lymphomagenesis by repressing apoptosis and implicate the functional diversity of miRNAs as the molecular basis for its pleiotropic effects during tumorigenesis.