Gregory C. Whitlock
University of Texas Medical Branch
13 Papers
108 Citations
Gregory C. Whitlock is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Burkholderia mallei & Burkholderia. The author has an hindex of 9, co-authored 13 publications.
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Papers
Protective response to subunit vaccination against intranasal Burkholderia mallei and B. pseudomallei challenge.
Gregory C. Whitlock,Arpaporn Deeraksa,Omar I Qazi,Barbara M. Judy,Katherine Taylor,Katie L. Propst,Angie J. Duffy,Kate M. Johnson,G. Barrie Kitto,Katherine A. Brown,Steven W. Dow,Alfredo G. Torres,D. Mark Estes +12 more
TL;DR: It was indicated that it was possible to elicit cross-protective immunity against both B. mallei and B. pseudomallei by vaccinating animals with one or more novel recombinant proteins identified in B.mallei.
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Host immunity in the protective response to vaccination with heat-killed Burkholderia mallei
Gregory C. Whitlock,Roman A. Lukaszewski,Barbara M. Judy,Slobodan Paessler,Alfredo G. Torres,D. Mark Estes +5 more
TL;DR: The data provide a basis for future studies of protection via vaccination using either subunit or whole-organism vaccine preparations from lethal infection in the experimental BALB/c mouse model and provide insight into potential host protective mechanisms.
Comparison of the in vitro and in vivo susceptibilities of Burkholderia mallei to Ceftazidime and Levofloxacin.
TL;DR: Both antibiotics demonstrated utility for the treatment of glanders, including the ability for intracellular penetration and clearance of organisms in vitro.
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Protective antigens against glanders identified by expression library immunization
Gregory C. Whitlock,Mark D. Robida,Barbara M. Judy,Omar I Qazi,Katherine A. Brown,Arpaporn Deeraksa,Katherine Taylor,Shane Massey,Andrey Loskutov,Alex Y. Borovkov,Kevin Brown,Jose A. Cano,Alfredo G. Torres,D. Mark Estes,Kathryn Sykes +14 more
TL;DR: It is suggested that these pathogen components, discovered using genetic immunization and confirmed in a conventional protein format, will be useful toward the development of a safe and effective glanders vaccine.
Construction of a reporter system to study Burkholderia mallei type III secretion and identification of the BopA effector protein function in intracellular survival.
TL;DR: This study elucidates how BopA can aid in the optimization of TTS and defines the function of T TS effectors in bacterial intracellular survival and invasion and Construction of the TTSS bopA mutant revealed that Bop a is important for B. mallei invasion and intrace cellular survival.
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