Gregg McAllister
Novartis
3 Papers
Gregg McAllister is an academic researcher from Novartis. The author has contributed to research in topics: Protein arginine methyltransferase 5 & Prostate cancer. The author has an hindex of 2, co-authored 3 publications.
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Papers
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Konstantinos J. Mavrakis,E. Robert McDonald,Michael R. Schlabach,Eric Billy,Gregory R. Hoffman,Antoine deWeck,David A. Ruddy,Kavitha Venkatesan,Jianjun Yu,Gregg McAllister,Mark Stump,Rosalie deBeaumont,Samuel B. Ho,Yingzi Yue,Yue Liu,Yan Yan-Neale,Guizhi Yang,Fallon Lin,Hong Yin,Hui Gao,D. Randal Kipp,Songping Zhao,Joshua T. McNamara,Elizabeth R. Sprague,Bing Zheng,Ying Lin,Young Shin Cho,Justin Gu,Kenneth Crawford,David N. Ciccone,Alberto C. Vitari,Albert Lai,Vladimir Capka,Kristen Hurov,Jeffery A. Porter,John A. Tallarico,Craig Mickanin,Emma Lees,Raymond Pagliarini,Nicholas Keen,Tobias Schmelzle,Francesco Hofmann,Frank Stegmeier,William R. Sellers +43 more
TL;DR: By interrogating data from a large-scale short hairpin RNA–mediated screen across 390 cancer cell line models, it is found that the viability of MTAP-deficient cancer cells is impaired by depletion of the protein arginine methyltransferase PRMT5.
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Author response: ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor
Zineb Mounir,Joshua M. Korn,Thomas Westerling,Fallon Lin,Christina A. Kirby,Markus Schirle,Gregg McAllister,Greg Hoffman,Nadire Ramadan,Anke Hartung,Yan Feng,David Randal Kipp,Christopher Quinn,Michelle Fodor,Jason Baird,Marie Schoumacher,Ronald Meyer,James Deeds,Gilles Buchwalter,Travis Stams,Nicholas Keen,William R. Sellers,Myles Brown,Raymond Pagliarini +23 more
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ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the androgen receptor
Zineb Mounir,Joshua M. Korn,Thomas Westerling,Fallon Lin,Christina A. Kirby,Markus Schirle,Gregg McAllister,Greg Hoffman,Nadire Ramadan,Anke Hartung,Yan Feng,David Randal Kipp,Christopher Quinn,Michelle Fodor,Jason Baird,Marie Schoumacher,Ronald Meyer,James Deeds,Gilles Buchwalter,Travis Stams,Nicholas Keen,William R. Sellers,Myles Brown,Raymond Pagliarini +23 more
TL;DR: Mutation of this methylation site on AR results in a transcriptionally hyperactive AR, suggesting that the proliferative effects of ERG and PRMT5 are mediated through attenuating AR’s ability to induce genes normally involved in lineage differentiation.