Greg Hoffman
Novartis
4 Papers
Greg Hoffman is an academic researcher from Novartis. The author has contributed to research in topics: Prostate cancer & Androgen receptor. The author has an hindex of 3, co-authored 4 publications.
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Papers
Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling.
Hui Wang,Bo Lu,Johnny Castillo,Yue Zhang,Zinger Yang,Gregory McAllister,Alicia Lindeman,John S. Reece-Hoyes,John A. Tallarico,Carsten Russ,Greg Hoffman,Wenqing Xu,Markus Schirle,Feng Cong +13 more
TL;DR: The data suggest that tankyrase inhibition could serve as a novel strategy to suppress YAP signaling for combinatorial targeted therapy.
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TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer.
Robert M. Witwicki,Muhammad B. Ekram,Xintao Qiu,Michalina Janiszewska,Shaokun Shu,Mijung Kwon,Anne Trinh,Elizabeth Frias,Nadire Ramadan,Greg Hoffman,Kristine Yu,Yingtian Xie,Gregory McAllister,Robert E McDonald,Javad Golji,Michael R. Schlabach,Antoine deWeck,Nicholas Keen,Ho Man Chan,David A. Ruddy,Tomas Rejtar,Sosathya Sovath,Serena J. Silver,William R. Sellers,Zainab Jagani,Michael D. Hogarty,Charles W. M. Roberts,Myles Brown,Kimberly Stegmaier,Henry W. Long,Ramesh A. Shivdasani,David Pellman,Kornelia Polyak +32 more
TL;DR: The TRPS1 transcription factor is described as a strong breast cancer-specific hit, owing largely to lineage-restricted expression, and a transcriptional network that is essential for breast cancer cell survival and propagation is uncovered.
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Author response: ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor
Zineb Mounir,Joshua M. Korn,Thomas Westerling,Fallon Lin,Christina A. Kirby,Markus Schirle,Gregg McAllister,Greg Hoffman,Nadire Ramadan,Anke Hartung,Yan Feng,David Randal Kipp,Christopher Quinn,Michelle Fodor,Jason Baird,Marie Schoumacher,Ronald Meyer,James Deeds,Gilles Buchwalter,Travis Stams,Nicholas Keen,William R. Sellers,Myles Brown,Raymond Pagliarini +23 more
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ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the androgen receptor
Zineb Mounir,Joshua M. Korn,Thomas Westerling,Fallon Lin,Christina A. Kirby,Markus Schirle,Gregg McAllister,Greg Hoffman,Nadire Ramadan,Anke Hartung,Yan Feng,David Randal Kipp,Christopher Quinn,Michelle Fodor,Jason Baird,Marie Schoumacher,Ronald Meyer,James Deeds,Gilles Buchwalter,Travis Stams,Nicholas Keen,William R. Sellers,Myles Brown,Raymond Pagliarini +23 more
TL;DR: Mutation of this methylation site on AR results in a transcriptionally hyperactive AR, suggesting that the proliferative effects of ERG and PRMT5 are mediated through attenuating AR’s ability to induce genes normally involved in lineage differentiation.