Greg Ekberg
GenVec
5 Papers
12 Citations
Greg Ekberg is an academic researcher from GenVec. The author has contributed to research in topics: Suppressor mutation & Plasmodium yoelii. The author has an hindex of 3, co-authored 5 publications. Previous affiliations of Greg Ekberg include University of California, Santa Barbara.
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Papers
The CDI toxin of Yersinia kristensenii is a novel bacterial member of the RNase A superfamily.
Gaëlle Batot,Karolina Michalska,Greg Ekberg,Ervin M Irimpan,Grazyna Joachimiak,Robert Jedrzejczak,Gyorgy Babnigg,Christopher S. Hayes,Andrzej Joachimiak,Andrzej Joachimiak,Celia W. Goulding +10 more
TL;DR: CdiA-CTYkris is the first non-vertebrate protein found to possess the RNase A superfamily fold, and homologs of this toxin are associated with secretion systems in many Gram-negative and Gram-positive bacteria, suggesting thatRNase A-like toxins are commonly deployed in inter-bacterial competition.
New gorilla adenovirus vaccine vectors induce potent immune responses and protection in a mouse malaria model.
Keith Limbach,Keith Limbach,Maureen E. Stefaniak,Maureen E. Stefaniak,Ping Chen,Noelle B. Patterson,Noelle B. Patterson,Grant Liao,Shaojie Weng,Svetlana Krepkiy,Greg Ekberg,Holly Torano,Damodar Ettyreddy,Kalpana Gowda,Sharvari Sonawane,Sharvari Sonawane,Arnel Belmonte,Arnel Belmonte,Esteban Abot,Esteban Abot,Martha Sedegah,Michael R. Hollingdale,Michael R. Hollingdale,Ann M. Moormann,John M. Vulule,Eileen Villasante,Thomas L. Richie,Douglas E. Brough,Joseph T. Bruder +28 more
TL;DR: The evaluation of the seroprevalence, immunogenicity and efficacy of three newly identified gorilla adenoviruses, GC44, GC45 and GC46, as potential malaria vaccine vectors suggest that these gorilla-based adenovectors have key performance characteristics for an effective malaria vaccine.
Identification of a Suppressor Mutation That Improves the Yields of Hexon-Modified Adenovirus Vectors
Joseph T. Bruder,Ping Chen,Elena Semenova,C. A. Thomas,Svetlana Konovalova,Greg Ekberg,Damodar Ettyreddy,Mcvey Duncan L,Jason G. D. Gall,C.R. King,D.E. Brough +10 more
TL;DR: It is determined that the hexon-modified vectors have a 32°C cold-sensitive phenotype and selected revertants that restored vector productivity, and a single base change resulting in a threonine-to-methionine amino acid substitution at the position equivalent to residue 342 of the wild-type protein has a suppressor phenotype.
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Profiling the Targets of Protective CD8+ T Cell Responses to Infection
Joseph T. Bruder,Ping Chen,Greg Ekberg,Emily C. Smith,Emily C. Smith,Christopher A. Lazarski,Bennett A. Myers,Jessica Bolton,Jessica Bolton,Martha Sedegah,Eileen Villasante,Thomas L. Richie,C. Richter King,Joao C. Aguiar,Denise L. Doolan,Douglas E. Brough +15 more
TL;DR: A novel approach for screening large numbers of antigens as potential targets of T cells following immunization with live sporozoite vaccines, and the antigen that recalled the highest frequency of CD8+ T cells, PY02605, induced protective responses in mice is reported, demonstrating proof of principle for this approach in identifying antigen for vaccine development.
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