Greg C. Mun
7 Papers
88 Citations
Greg C. Mun is an academic researcher. The author has contributed to research in topics: Genotoxicity & Micronucleus test. The author has an hindex of 6, co-authored 7 publications.
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Papers
Intralaboratory and interlaboratory evaluation of the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay
Ting Hu,Yulia Kaluzhny,Greg C. Mun,Brenda Barnett,Viktor Karetsky,Nathan Wilt,Mitchell Klausner,Rodger Curren,Marilyn J. Aardema +8 more
TL;DR: Results indicate the RSMN assay using the EpiDerm 3D human skin model is a promising new in vitro genotoxicity assay that allows evaluation of chromosome damage following "in vivo-like" dermal exposures.
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Evaluation of chemicals requiring metabolic activation in the EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay.
Marilyn J. Aardema,Brenda Barnett,Greg C. Mun,Erica L. Dahl,Rodger Curren,Nicola J. Hewitt,Stefan Pfuhler +6 more
TL;DR: It appears that the RMSN assay detects some chemicals that require metabolic activation, and the use of a longer treatment period in situations where the standard 48h treatment is negative or questionable is recommended.
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Using the cytosensor microphysiometer to assess ocular toxicity.
TL;DR: The Cytosensor Microphysiometer method evaluates cytotoxicity by measuring the test material–induced reduction in the metabolic rate of L929 cells, which shows a decrease in the release of acid byproducts into the surrounding medium as the cells die.
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Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm).
TL;DR: This paper describes the development of a reproducible micronucleus assay that uses EpiDerm engineered human skin constructs and describes methods for isolating single cells from the 3D skin model and for processing the cells for microscopic analysis ofmicronuclei (MN).
International prevalidation studies of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay: transferability and reproducibility.
Marilyn J. Aardema,Brenda C. Barnett,Zubin S. Khambatta,Kerstin Reisinger,Gladys Ouedraogo-Arras,Brigitte Faquet,Anne-Claire Ginestet,Greg C. Mun,Erica L. Dahl,Nicola J. Hewitt,Raffallea Corvi,Rodger Curren +11 more
TL;DR: The results support the international inter-laboratory and inter-experimental reproducibility of the assay and reinforce the conclusion that the RSMN assay in the EpiDerm 3D human skin model is a valuable in vitro method for assessment of genotoxicity of dermally applied chemicals.