Graham Marsh
Biogen Idec
17 Papers
23 Citations
Graham Marsh is an academic researcher from Biogen Idec. The author has contributed to research in topics: Chemistry & Kidney. The author has an hindex of 13, co-authored 17 publications. Previous affiliations of Graham Marsh include University of Rochester.
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Papers
A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport.
Nienke R. Wevers,Dhanesh G. Kasi,Taylor Gray,Karlijn Wilschut,Benjamin Smith,Remko van Vught,Fumitaka Shimizu,Yasuteru Sano,Takashi Kanda,Graham Marsh,Sebastiaan Johannes Trietsch,Paul Vulto,Henriëtte L. Lanz,Birgit Obermeier +13 more
TL;DR: This in vitro model shows sufficient barrier function to study the passage of large molecules and is sensitive to differences in antibody penetration, which could support discovery and engineering of BBB-shuttle technologies.
Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models
Andreas Weihofen,YuTing Liu,Joseph Arndt,Huy C,Chao Quan,Benjamin A. Smith,Baeriswyl Jl,Cavegn N,Senn L,Su L,Graham Marsh,Auluck Pk,Fabio Montrasio,Roger M. Nitsch,Warren D. Hirst,Cedarbaum Jm,R. B. Pepinsky,Jan Grimm,Paul H. Weinreb +18 more
TL;DR: BIIB054 treatment attenuated the spreading of α-syn pathology, rescued motor impairments, and reduced the loss of dopamine transporter density in dopaminergic terminals in striatum in mouse models of PD.
164
Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging.
Mootaz M. Salman,Mootaz M. Salman,Graham Marsh,Ilja Kusters,Ilja Kusters,Matthieu Delince,Matthieu Delince,Giuseppe Di Caprio,Giuseppe Di Caprio,Srigokul Upadhyayula,Srigokul Upadhyayula,Giovanni de Nola,Giovanni de Nola,Ronan Hunt,Kazuka G. Ohashi,Taylor Gray,Fumitaka Shimizu,Yasuteru Sano,Takashi Kanda,Birgit Obermeier,Tom Kirchhausen,Tom Kirchhausen +21 more
TL;DR: This work miniaturized the design, so it can fit within the physical constraints of LLSM, with the objective to study physiology in live cells at subcellular level and validated barrier function of the brain microvessel-on-a-chip.
Binding Force Dynamics of Streptococcus mutans–glucosyltransferase B to Candida albicans
TL;DR: The data provide the first insights into the mechanisms underlying the adhesive and mechanical properties governing GtfB interactions with C. albicans, and could explain, at least in part, why this bacterially derived exoenzyme effectively modulates this virulent cross-kingdom interaction.
87
Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis
Bryce G. Johnson,Lan T.H. Dang,Graham Marsh,Allie M. Roach,Allie M. Roach,Zebulon G. Levine,Anthony Monti,Deepak Reyon,Lionel Feigenbaum,Jeremy S. Duffield,Jeremy S. Duffield,Jeremy S. Duffield +11 more
TL;DR: Blocking TNF-&agr; in vivo with the soluble recombinant fusion protein TNFR:Fc slowed disease progression in UmodC147W/+ mice by reducing active caspase-3, thereby preventing tubule cell death and loss of epithelial function.