Graeme Williams
University of Reading
5 Papers
3 Citations
Graeme Williams is an academic researcher from University of Reading. The author has contributed to research in topics: Aromatase & Environmental Carcinogenesis. The author has an hindex of 4, co-authored 5 publications.
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Papers
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead
William H. Goodson,Leroy Lowe,David O. Carpenter,Michael Gilbertson,Abdul Manaf Ali,Adela Lopez de Cerain Salsamendi,Ahmed Lasfar,Amancio Carnero,Amaya Azqueta,Amedeo Amedei,Amelia K Charles,Andrew Collins,Andrew Ward,Anna C. Salzberg,Annamaria Colacci,Ann-Karin Olsen,Arthur Berg,Barry J. Barclay,Binhua P. Zhou,Carmen Blanco-Aparicio,Carolyn J. Baglole,Chenfang Dong,Chiara Mondello,Chia-Wen Hsu,Christian C. Naus,Clement G. Yedjou,Colleen S. Curran,Dale W. Laird,Daniel C. Koch,Danielle J Carlin,Dean W. Felsher,Debasish Roy,Dustin G. Brown,Edward A. Ratovitski,Elizabeth P. Ryan,Emanuela Corsini,Emilio Rojas,Eun-Yi Moon,Ezio Laconi,Fabio Marongiu,Fahd Al-Mulla,Ferdinando Chiaradonna,Firouz Darroudi,Francis Martin,Frederik J. van Schooten,Gary S. Goldberg,Gerard Wagemaker,Gladys N. Nangami,Gloria M. Calaf,Gloria M. Calaf,Graeme Williams,Gregory T. Wolf,Gudrun Koppen,Gunnar Brunborg,H. Kim Lyerly,Harini Krishnan,Hasiah Ab Hamid,Hemad Yasaei,Hideko Sone,Hiroshi Kondoh,Hosni Salem,Hsue-Yin Hsu,Hyun Ho Park,Igor Koturbash,Isabelle R. Miousse,A. Ivana Scovassi,James E. Klaunig,Jan Vondráček,Jayadev Raju,Jesse Roman,Jesse Roman,John Pierce Wise,Jonathan Whitfield,Jordan Woodrick,Joseph Christopher,Josiah Ochieng,Juan Fernando Martinez-Leal,Judith Weisz,Julia Kravchenko,Jun Sun,Kalan R. Prudhomme,Kannan Badri Narayanan,Karine A. Cohen-Solal,Kim Moorwood,Laetitia Gonzalez,Laura Soucek,Le Jian,Leandro S. D'Abronzo,Liang Tzung Lin,Lin Li,Linda S M Gulliver,Lisa J. McCawley,Lorenzo Memeo,Louis Vermeulen,Luc Leyns,Luoping Zhang,Mahara Valverde,Mahin Khatami,Maria Romano,Marion Chapellier,Marc A. Williams,Mark Wade,Masoud H. Manjili,Matilde E. Lleonart,Menghang Xia,Michael J. Gonzalez,Michalis V. Karamouzis,Micheline Kirsch-Volders,Monica Vaccari,Nancy B. Kuemmerle,Nancy B. Kuemmerle,Neetu Singh,Nichola Cruickshanks,Nicole Kleinstreuer,Nik van Larebeke,Nuzhat Ahmed,Olugbemiga Ogunkua,Periyadan K. Krishnakumar,Pankaj Vadgama,Paola A. Marignani,Paramita M. Ghosh,Patricia Ostrosky-Wegman,Patricia A. Thompson,Paul Dent,Petr Heneberg,Philippa D. Darbre,Po Sing Leung,Pratima Nangia-Makker,Qiang Shawn Cheng,R. Brooks Robey,R. Brooks Robey,Rabeah Al-Temaimi,Rabindra Roy,Rafaela Andrade-Vieira,Ranjeet Kumar Sinha,Rekha Mehta,Renza Vento,Renza Vento,Riccardo Di Fiore,Richard Ponce-Cusi,Rita Dornetshuber-Fleiss,Rita Dornetshuber-Fleiss,Rita Nahta,Robert C. Castellino,Roberta Palorini,Roslida Abd Hamid,Sabine A. S. Langie,Sakina E. Eltom,Samira A. Brooks,Sandra Ryeom,Sandra S. Wise,Sarah N Bay,Shelley A. Harris,Shelley A. Harris,Silvana Papagerakis,Simona Romano,Sofia Pavanello,Staffan Eriksson,Stefano Forte,Stephanie C. Casey,Sudjit Luanpitpong,Tae-Jin Lee,Takemi Otsuki,Tao Chen,Thierry Massfelder,Thomas Sanderson,Tiziana Guarnieri,Tove Hultman,Valérian Dormoy,Valérian Dormoy,Valerie Odero-Marah,Venkata S. Sabbisetti,Véronique Maguer-Satta,W. Kimryn Rathmell,Wilhelm Engström,William K. Decker,William H. Bisson,Yon Rojanasakul,Yunus A. Luqmani,Zhenbang Chen,Zhiwei Hu +180 more
TL;DR: Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer.
Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?
R. Brooks Robey,R. Brooks Robey,Judith Weisz,Nancy B. Kuemmerle,Anna C. Salzberg,Arthur Berg,Dustin G. Brown,Laura L. Kubik,Roberta Palorini,Fahd Al-Mulla,Rabeah Al-Temaimi,Annamaria Colacci,Chiara Mondello,Jayadev Raju,Jordan Woodrick,A. Ivana Scovassi,Neetu Singh,Monica Vaccari,Rabindra Roy,Stefano Forte,Lorenzo Memeo,Hosni Salem,Amedeo Amedei,Roslida Abd Hamid,Graeme Williams,Leroy Lowe,Joel N. Meyer,Francis Martin,William H. Bisson,Ferdinando Chiaradonna,Elizabeth P. Ryan +30 more
TL;DR: A literature review to identify environmentally relevant exposures unambiguously linked to both cancer development and dysregulated metabolism suggests major gaps in understanding of exposure-associated carcinogenesis and metabolic reprogramming.
Low-dose environmental endocrine disruptors, increase aromatase activity, estradiol biosynthesis and cell proliferation in human breast cells.
TL;DR: Inadvertent exposures to 'phenolic' EDCs, increase estradiol biosynthesis, and estrogen-sensitive breast cancer proliferation, in humans exposed to seven phenolic compounds at environmentally relevant concentrations.
64
Endocrine Disruption and Cancer of Reproductive Tissues
Philippa D. Darbre,Graeme Williams +1 more
- 01 Jan 2015
TL;DR: The potential for endocrine-disrupting chemicals (EDCs) to influence the development of cancer in female endocrin-sensitive tissues of the breast, endometrium, ovary, and cervix, and in male hormone-regulated tissue of the prostate, testis, and breast is discussed.
5
Aromatase up-regulation, insulin and raised intracellular oestrogens in men, induce adiposity, metabolic syndrome and prostate disease, via aberrant ER-α and GPER signalling
TL;DR: To understand this fact, that raised intracellular oestradiol levels in men, induce and promote obesity, gynecomastia, metabolic syndrome, type two diabetes, benign prostatic hypertrophy and prostate cancer, rather than low testosterone, represents a shift in medical thinking, a new awareness, that will reduce the rising incidence of obesity, metabolic Syndrome and prostate disease, and significantly improve the health of men worldwide.