Grace Madzinga
James Cook University Hospital
6 Papers
Grace Madzinga is an academic researcher from James Cook University Hospital. The author has contributed to research in topics: Medicine & Bolus (medicine). The author has an hindex of 3, co-authored 6 publications. Previous affiliations of Grace Madzinga include South Tees Hospitals NHS Trust.
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Papers
Bolus intrathecal injection of Ziconotide (Prialt®) to evaluate the option of continuous administration via an Implanted Intrathecal Drug Delivery (ITDD) System: a pilot study
Salma Mohammed,Sam Eldabe,Karen H. Simpson,Morag Brookes,Grace Madzinga,Ashish Gulve,Ganesan Baranidharan,Helen Radford,Tracey Crowther,Eric Buchser,Christophe Perruchoud,Alan M. Batterham +11 more
TL;DR: This study evaluated efficacy and safety of bolus doses of ziconotide (Prialt®, Eisai Limited, Hertfordshire, UK) to assess the option of continuous administration of this drug via an implanted intrathecal drug delivery system.
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Effects of flow rate modifications on reported analgesia and quality of life in chronic pain patients treated with continuous intrathecal drug therapy.
Christophe Perruchoud,Sam Eldabe,Anne Durrer,Michèle Bovy,Morag Brookes,Grace Madzinga,Fay Garner,Alan M. Batterham,Carole Menoud,Myriam Jacobs,Ash Gulve,Eric Buchser +11 more
TL;DR: The quality of life and the analgesia of a constant daily dose of intrathecal drug administered at different flow rates in patients treated for chronic pain are compared to suggest that at higher flow rates increased drug dilution results in a decreased effect at the receptor site.
Analgesic Efficacy of "Burst" and Tonic (500 Hz) Spinal Cord Stimulation Patterns: A Randomized Placebo-Controlled Crossover Study.
Sam Eldabe,Rui V. Duarte,Ashish Gulve,Heather Williams,Fay Garner,Morag Brookes,Grace Madzinga,Eric Buchser,Alan M. Batterham +8 more
TL;DR: The aim of this study was to compare the efficacy in reducing pain intensity in adult subjects suffering from chronic back and leg pain of burst and tonic sub‐threshold stimulation at 500 Hz and sham stimulation delivered by a spinal cord stimulation (SCS) device capable of automated postural adjustment of current intensity.
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A prospective long-term follow-up of dorsal root ganglion stimulation for the management of chronic intractable pain
Sam Eldabe,Sue Copley,Ashish Gulve,Ganesan Baranidharan,Beatrice Bretherton,Anu Kansal,Grace Madzinga,Morag Brookes,Simon Thomson,Rui V. Duarte +9 more
TL;DR: In conclusion, DRG stimulation can provide effective pain relief and improved quality of life in patients suffering with neuropathic pain, although this study had a revision rate of 42% within the first 24 months, and 56% of IPGs that were replaced because of battery depletion had a shorter than expected battery life.
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Comparison of the Effects of Intermittent Boluses to Simple Continuous Infusion on Patients’ Global Perceived Effect in Intrathecal Therapy for Pain: A Randomized Double-Blind Crossover Study
Sam Eldabe,Rui V. Duarte,Grace Madzinga,Alan M. Batterham,Morag Brookes,Ashish Gulve,Christophe Perruchoud,Jon H. Raphael,David Lorenzana,Eric Buchser +9 more
TL;DR: The mean PGIC and proportion of positive responders was not substantially different after intermittent bolus vs continuous administration, and Exploratory analyses revealed a tendency for the mean proportion ofpositive responders to be higher at low vs high flow rates for both bolus and continuous administrations.
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