Grace Egan
University of Toronto
19 Papers
24 Citations
Grace Egan is an academic researcher from University of Toronto. The author has contributed to research in topics: Medicine & Hematopoietic stem cell transplantation. The author has an hindex of 6, co-authored 15 publications. Previous affiliations of Grace Egan include New York University & University of Limerick.
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Papers
Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality
Jo Ishizawa,Sarah F. Zarabi,Sarah F. Zarabi,R. Eric Davis,Ondrej Halgas,Ondrej Halgas,Takenobu Nii,Yulia Jitkova,Ran Zhao,Jonathan St-Germain,Lauren Heese,Grace Egan,Vivian Ruvolo,Samir H. Barghout,Samir H. Barghout,Yuki Nishida,Rose Hurren,Wencai Ma,Marcela Gronda,Todd M. Link,Keith S. Wong,Keith S. Wong,Mark F. Mabanglo,Kensuke Kojima,Kensuke Kojima,Gautam Borthakur,Neil MacLean,Man Chun John Ma,Andrew B. Leber,Mark D. Minden,Mark D. Minden,Walid A. Houry,Hagop M. Kantarjian,Martin Stogniew,Brian Raught,Brian Raught,Emil F. Pai,Aaron D. Schimmer,Aaron D. Schimmer,Michael Andreeff +39 more
TL;DR: It is shown that imipridones bind ClpP non-covalently and induce proteolysis by diverse structural changes, suggesting a general concept of inducing cancer cell lethality through activation of mitochondrial proteolytic activity.
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Ultrasound guidance for difficult peripheral venous access: systematic review and meta-analysis
Grace Egan,Donagh Healy,Heidi O'Neill,Mary Clarke-Moloney,Pierce A. Grace,Stewart R. Walsh,Stewart R. Walsh +6 more
TL;DR: This systematic review and meta-analysis aimed to determine the clinical effectiveness of Ultrasound-guided peripheral intravenous cannulation compared with the standard technique in patients known to have difficult access and recommended its use in patients who have difficult venous access.
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Guideline for Antibacterial Prophylaxis Administration in Pediatric Cancer and Hematopoietic Stem Cell Transplantation.
Thomas Lehrnbecher,Brian T. Fisher,Bob Phillips,Bob Phillips,Sarah Alexander,Roland A. Ammann,Melissa Beauchemin,Fabianne Carlesse,Elio Castagnola,Bonnie L. Davis,L. Lee Dupuis,Grace Egan,Andreas H. Groll,Gabrielle M Haeusler,Gabrielle M Haeusler,María Elena Santolaya,William J. Steinbach,Marianne D. van de Wetering,Joshua Wolf,Sandra Cabral,Paula D. Robinson,Lillian Sung +21 more
TL;DR: A CPG for systemic antibacterial prophylaxis administration in pediatric cancer and HSCT patients is presented and a strong recommendation against its routine use was made for children whose therapy is not expected to result in prolonged severe neutropenia.
Mitochondrial and Metabolic Pathways Regulate Nuclear Gene Expression to Control Differentiation, Stem Cell Function, and Immune Response in Leukemia
Grace Egan,Grace Egan,Dilshad H. Khan,Jong Bok Lee,Sara Mirali,Sara Mirali,Li Zhang,Aaron D. Schimmer +7 more
TL;DR: In this article, a review highlights how mitochondrial and metabolic pathways function as a central mediator to control gene expression, specifically on stem cell functions, differentiation, and immune response in leukemia.
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Omission of the bladder flap at caesarean section reduces delivery time without increased morbidity: a meta-analysis of randomised controlled trials
TL;DR: Omission of the BF at elective CS does not appear to increase the rate of peri-operative complications and improves the skin incision-delivery interval, and the role of BF formation in very preterm procedures and emergency intrapartum CS needs further study.
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