Grace Chen
Research Triangle Park
12 Papers
292 Citations
Grace Chen is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Agonist & Receptor. The author has an hindex of 8, co-authored 11 publications.
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Papers
•Journal Article
Use of constitutive G protein-coupled receptor activity for drug discovery.
Grace Chen,James M. Way,Susan Armour,Chris Watson,Ken Queen,Channa Jayawickreme,Wen Ji Chen,Terry P. Kenakin +7 more
TL;DR: The behavior of transiently transfected human receptors into melanophores and the potential use of constitutive receptor activity to screen for new drug entities are described and the applicability of this approach for the general screening of G protein-coupled orphan receptors is discussed.
118
Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)
Steven M. Sparks,Grace Chen,Jon L. Collins,Dana P. Danger,Dock Steven Thomas,Channa K Jayawickreme,Stephen Jenkinson,Christopher P. Laudeman,M. Anthony Leesnitzer,Xi Liang,Patrick R. Maloney,David C McCoy,David Moncol,Vincent Rash,Thomas J. Rimele,Padmaja Vulimiri,James M. Way,Sean Ross +17 more
TL;DR: The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described, which led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective F FA4 antagonist 39.
104
The use of stimulus-biased assay systems to detect agonist-specific receptor active states: implications for the trafficking of receptor stimulus by agonists.
TL;DR: Data is presented to show that a single receptor can demonstrate varying agonist potency ratios in different host cells, consistent with the idea that these different agonists produce arrays of active states that differentially use G proteins.
103
Expression Cloning and Receptor Pharmacology of Human Calcitonin Receptors from MCF-7 Cells and Their Relationship to Amylin Receptors
Wen Ji Chen,Susan Armour,James M. Way,Grace Chen,Chris Watson,Paul E. Irving,Jeff E. Cobb,Sue H. Kadwell,Kevin Beaumont,Thomas J. Rimele,Terry P. Kenakin +10 more
TL;DR: Human breast cell carcinoma MCF-7 cells were found to bind 125I-labeled rat amylin (rAmylin) and the peptide isylin antagonist radioligand125I-AC512 with high affinity, and the agonists hCAL and rAmylin were much more potent in displacing their radiolIGand counterparts than was the antagonist radiolaigand 125I -AC512.
78
Constitutive receptor systems for drug discovery.
Grace Chen,Channa K Jayawickreme,James M. Way,Susan Armour,Ken Queen,Chris Watson,Diane M. Ignar,Wen Ji Chen,Terrence Peter Kenakin +8 more
TL;DR: In experimental studies, transient transfection of Chinese hamster ovary cyclic AMP response element (CRE) luciferase reporter cells with cDNA for human parathyroid hormone receptor, glucagon receptor, and glucagon-like peptide receptor showed cDNA concentration-dependent constitutive activity.
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