Gordon Lauc
5 Papers
12 Citations
Gordon Lauc is an academic researcher. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 1, co-authored 1 publications.
Chat about Author
Papers
HnRNP CBP35.CBP67 interaction during stress response and ageing.
Gordon Lauc,Annie-Pierre Sève,Jean Hubert,Mirna Flögel-Mrsic,Werner E.G. Müller,Heinz C. Schröder +5 more
TL;DR: It is shown that the exposure of mature rats to stress induces an increase in nuclear CBP35 bound to CBP67 and retained on immobilized glucose, which is consistent with the proposed role of this protein to guide RNP complexes through the nuclear pore.
12
Mapping of the gene network that regulates glycan clock of ageing
A. Frkatovic-Hodzic,Karlo Miškec,Anika Mijakovac,Arina V. Nostaeva,Sodbo Zh Sharapov,A. Landini,Toomas Haller,Erik B. van den Akker,Rafael R. C. Cuadrat,Massimo Mangino,Y. Li,Toma Keser,Najda Rudman,Tamara Štambuk,Maja Pučić-Baković,Irena Trbojević-Akmačić,Ivana Gudelj,Jerko Štambuk,Teodora Pribic,B.Angeli Radovani,Petra Tominac,Katrin Fischer,Marian Beekman,Manfred Wuhrer,Christian Gieger,Mattes Schulze,Clemens Wittenbecher,Ozren Polasek,Caroline Hayward,J. F. Wilson,Tim D. Spector,A. Kottgen,Frano Vučković,Yurii S. Aulchenko,Aleksandar Vojta,Jasminka Krištić,Lucija Klaric,Vlatka Zoldoš,Gordon Lauc +38 more
TL;DR: In this paper , the authors performed a genome-wide association study (GWAS) of Immunoglobulin G (IgG) and identified 16 significantly associated loci, indicating that IgG galactosylation is regulated by a complex network of genes that extends beyond the galactosa enzyme that adds galactose to IgG glycans.
5
Effects of testosterone and metformin on the GlycanAge index of biological age and the composition of the IgG glycome
M. Vinicki,Tea Pribić,F. Vuckovic,A. Frkatovic-Hodzic,I. Plaza-Andrade,F. Tinahones,J. Raffaele,J. C. Fernandez-Garcia,Gordon Lauc +8 more
TL;DR: The value of IgG glycosylation as a significant biomarker, capable of assessing biological age using the GlycanAge index and providing insight into overall health compared to chronological age, is confirmed.
2
Exome sequencing reveals aggregates of rare variants in glycosyltransferase and other genes influencing immunoglobulin G and transferrin glycosylation
A. Landini,Paul R. H. J. Timmers,A. Frkatovic-Hodzic,Irena Trbojević-Akmačić,Frano Vučković,Teodora Pribic,Regeneron Genetics Center,Gannie Tzoneva,A. Shuldiner,Ozren Polasek,Caroline Hayward,Gordon Lauc,J. F. Wilson,Lucija Klaric +13 more
TL;DR: In this paper , the authors used the power of genetic isolates, gene-based aggregation tests and intermediate phenotypes to assess the effect of rare (MAF < 5%) pLoF and missense variants from whole exome sequencing on the N-glycome of plasma transferrin and immunoglobulin G (N=1907) and their effect on diseases.
The Molecular Human -- A Roadmap of Molecular Interactions Linking Multiomics Networks with Disease Endpoints.
Anna Halama,Shaza B. Zaghlool,Gaurav Thareja,Sara Abdul Kader,W. Al Muftha,Marjonneke J. Mook-Kanamori,Hina Sarwath,Yasmin Ali Mohamoud,Sabine Ameling,Maja Pučić Baković,Jan Krumsiek,Cornelia Prehn,Jerzy Adamski,Nina Friedrich,U. Voelker,Manfred Wuhrer,Gordon Lauc,Hadi Najafi,Julie A. Malek,Johannes Graumann,Dennis O. Mook-Kanamori,Frank Schmidt,Karsten Suhre +22 more
TL;DR: In this article , the authors report on the application of 18 diverse deep molecular phenotyping (omics-) technologies to urine, blood, and saliva samples from 391 participants of the multiethnic diabetes study QMDiab.