Gonçalo R. Abecasis
University of Michigan
650 Papers
13.5K Citations
Gonçalo R. Abecasis is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Biology. The author has an hindex of 179, co-authored 595 publications. Previous affiliations of Gonçalo R. Abecasis include Johns Hopkins University School of Medicine & Wellcome Trust Centre for Human Genetics.
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Papers
Correction: Corrigendum: Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies
TL;DR: In Table 1 of the versions of this article initially published online and in print, the significance thresholds for C2 were incorrect, and the significance threshold for Cjoint in the case of πsamples = 0.20 were incorrect.
Prosaposin is a regulator of progranulin levels and oligomerization
Alexandra M. Nicholson,Ni Cole A. Finch,Marcio Almeida,Ralph B. Perkerson,Marka van Blitterswijk,Aleksandra Wojtas,Basar Cenik,Sergio Rotondo,Venette Inskeep,Laura Almasy,Thomas D. Dyer,Juan M. Peralta,Goo Jun,Andrew R. Wood,Timothy M. Frayling,Christian Fuchsberger,Sharon P. Fowler,Tanya M. Teslovich,Alisa K. Manning,Satish Kumar,Joanne E. Curran,Donna M. Lehman,Gonçalo R. Abecasis,Ravindranath Duggirala,Cyril Pottier,Haaris A. Zahir,Julia E. Crook,Anna Karydas,Laura L. Mitic,Ying Sun,Dennis W. Dickson,Guojun Bu,Joachim Herz,Gang Yu,Bruce L. Miller,Shawn M. Ferguson,Ronald C. Petersen,Neill R. Graff-Radford,John Blangero,Rosa Rademakers +39 more
TL;DR: It is shown that both PSAP reduction and overexpression lead to significantly elevated extracellular P GRN levels, and PSAP-induced changes in PGRN levels and oligomerization replicate in human-derived fibroblasts obtained from a GRN mutation carrier, further supporting PSAP as a potential PGRn-related therapeutic target.
Prevalence of CKD and Its Relationship to eGFR-Related Genetic Loci and Clinical Risk Factors in the SardiNIA Study Cohort
Antonello Pani,Jennifer L. Bragg-Gresham,Marco Masala,Doloretta Piras,Alice Atzeni,Maria Grazia Pilia,Liana Anna Pina Ferreli,Lenuta Balaci,Nicolò Curreli,Alessandro P Delitala,Francesco Loi,Gonçalo R. Abecasis,David Schlessinger,Francesco Cucca +13 more
TL;DR: Diabetes was associated with CKD prevalence, whereas hypertension and hyperuricemia correlated more strongly with fast eGFR decline, and diabetes, hypertension, hyperuricaemia, and high baseline eGfr were associated with a decline of eG FR.
Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models.
Johann E. Gudjonsson,Jun Ding,Andrew Johnston,Trilokraj Tejasvi,Andrew M. Guzman,Rajan P. Nair,John J. Voorhees,Gonçalo R. Abecasis,James T. Elder,James T. Elder +9 more
TL;DR: This comprehensive analysis of differentially regulated transcripts in psoriasis provides additional insight into the pathogenic mechanisms involved and emphasizes the need for more complex yet tractable experimental models of psoriatic disease.
Mapping the 17q12-21.1 Locus for Variants Associated with Early-onset Asthma in African Americans
Hongsheng Gui,Albert M. Levin,Donglei Hu,Patrick M. A. Sleiman,Shujie Xiao,Angel C.Y. Mak,Mao Yang,Andrea J. Barczak,Scott Huntsman,Celeste Eng,Samantha Hochstadt,Ellen Zhang,Kyle Whitehouse,Samantha Simons,Whitney Cabral,Sami Takriti,Gonçalo R. Abecasis,Thomas W. Blackwell,Hyun Min Kang,Deborah A. Nickerson,Soren Germer,David E. Lanfear,Frank D. Gilliland,W. James Gauderman,Rajesh Kumar,David J. Erle,Fernando D. Martinez,Hakon Hakonarson,Esteban G. Burchard,L. Keoki Williams +29 more
TL;DR: A splice acceptor polymorphism appears to be a causal variant for asthma at the 17q12-21.1 locus that appears to have the same magnitude of effect in individuals of African and European descent.