Gohar Mosoyan
Icahn School of Medicine at Mount Sinai
22 Papers
29 Citations
Gohar Mosoyan is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Renal function. The author has an hindex of 4, co-authored 9 publications.
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Papers
Derivation and validation of a machine learning risk score using biomarker and electronic patient data to predict progression of diabetic kidney disease.
Lili Chan,Girish N. Nadkarni,Fergus Fleming,James R. McCullough,Patricia Connolly,Gohar Mosoyan,Fadi Salem,Michael W. Kattan,Joseph A. Vassalotti,Barbara Murphy,Michael J. Donovan,Steven G. Coca,Scott M. Damrauer +12 more
TL;DR: In this article, a machine-learned, prognostic risk score (KidneyIntelX) combining electronic health records (EHR) and biomarkers was developed for predicting a composite outcome of eGFR decline of ≥5ml/min per year, ≥40% sustained decline, or kidney failure within 5 years.
Hyperglycemia is Associated With Increased Mortality in Critically Ill Patients With COVID-19.
Alon Yehuda Mazori,Ilana Bass,Lili Chan,Kusum S. Mathews,Deena R. Altman,Aparna Saha,Howard Soh,Huei Hsun Wen,Sonali Bose,Emily Leven,Jing Gennie Wang,Gohar Mosoyan,Pattharawin Pattharanitima,Giampaolo Greco,Emily J. Gallagher +14 more
TL;DR: In this paper, the authors explore the relationship between hyperglycemia in the presence and absence of diabetes mellitus and adverse outcomes in critically ill patients with coronavirus disease 2019 (COVID-19).
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Plasminogenuria is associated with podocyte injury, edema, and kidney dysfunction in incident glomerular disease
Marc A. Egerman,Jenny Wong,Tian Runxia,Gohar Mosoyan,Kinsuk Chauhan,Joselyn Reyes-Bahamonde,Nanditha Anandakrishnan,Nicholas J. Wong,Emilia Bagiella,Fadi Salem,Kristin Meliambro,Hong Li,Evren U. Azeloglu,Steven G. Coca,Kirk N. Campbell,Leopoldo Raij +15 more
TL;DR: A role for plasmin (ogen)‐induced podocyte injury in the PAN nephropathy model is demonstrated, with amiloride having podocytes‐protective properties and as a viable targetable biomarker for podocyte‐sparing treatments.
Analytical validation of a multi-biomarker algorithmic test for prediction of progressive kidney function decline in patients with early-stage kidney disease.
Patricia Connolly,Sharon Stapleton,Gohar Mosoyan,Ilya Fligelman,Ya-Chen Tonar,Fergus Fleming,Michael J. Donovan +6 more
TL;DR: The KidneyIntelX test as discussed by the authors applies a machine learning algorithm that incorporates plasma biomarkers and clinical variables to produce a composite risk score to predict a progressive decline in kidney function in patients with type 2 diabetes (T2D) and early-stage chronic kidney disease (CKD).
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Relieving DYRK1A repression of MKL1 confers an adult-like phenotype to human infantile megakaryocytes
Kamaleldin E. Elagib,Ashton T. Brock,Cara Clementelli,Gohar Mosoyan,Lorrie L. Delehanty,Ranjit Sahu,Alexandra Pacheco-Benichou,Corinne Fruit,Thierry Besson,Stephan W. Morris,Koji Eto,Chintan D Jobaliya,Deborah L. French,Paul Gadue,Sandeep Singh,Xinrui Shi,Fujun Qin,Robert Cornelison,Hui Li,Camelia Iancu-Rubin,Ada Goldfarb +20 more
TL;DR: A pharmacologically tractable morphogenetic pathway whose manipulation may alleviate clinical problems associated with the limited thrombopoietic capacity of infantile Mks is delineated.
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