Glenn Barnes
Harvard University
19 Papers
153 Citations
Glenn Barnes is an academic researcher from Harvard University. The author has contributed to research in topics: Huntington's disease & Gene. The author has an hindex of 16, co-authored 19 publications.
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Papers
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
Marcy E. MacDonald,Christine Ambrose,Mabel P. Duyao,Richard H. Myers,Carol Lin,Lakshmi Srinidhi,Glenn Barnes,Sherryl A.M. Taylor,Marianne James,Nicolet Groot,Heather MacFarlane,Barbara Jenkins,Mary Anne Anderson,Nancy S. Wexler,James F. Gusella,Gillian P. Bates,Sarah Baxendale,Holger Hummerich,Susan F. Kirby,Mike North,S. Youngman,Richard Mott,Günther Zehetner,Zdenek Sedlacek,Annemarie Poustka,Anna-Maria Frischauf,Hans Lehrach,Alan Buckler,Deanna M. Church,Lynn Doucette-Stamm,Michael Conlon O'Donovan,Laura Riba-Ramirez,Manish A. Shah,Vincent P. Stanton,Scott A. Strobel,Karen M. Draths,Jennifer L. Wales,Peter B. Dervan,David E. Housman,Michael R. Altherr,Rita Shiang,Leslie M. Thompson,Thomas J. Fielder,John J. Wasmuth,Danilo A. Tagle,John Valdes,Lawrence W. Elmer,Marc W. Allard,Lucio H. Castilla,Manju Swaroop,Kris Blanchard,Francis S. Collins,Russell G. Snell,Tracey Holloway,Kathleen Gillespie,Nicole A. Datson,Duncan Shaw,Peter S. Harper +57 more
TL;DR: In this article, the authors used haplotype analysis of linkage disequilibrium to spotlight a small segment of 4p16.3 as the likely location of the defect, which is expanded and unstable on HD chromosomes.
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Inactivation of the mouse Huntington's disease gene homolog Hdh.
Mabel P. Duyao,Anna Auerbach,Angela Ryan,Francesca Persichetti,Glenn Barnes,Sandra M. McNeil,P. Ge,Jean-Paul Vonsattel,James F. Gusella,Alexandra L. Joyner,Marcy E. MacDonald +10 more
TL;DR: That Hdh inactivation does not mimic adult HD neuropathology suggests that the human disease involves a gain of function, and that huntingtin is critical early in embryonic development, before the emergence of the nervous system.
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Huntingtin Interacts with a Family of WW Domain Proteins
Peter W. Faber,Glenn Barnes,Jayalakshmi Srinidhi,Jianmin Chen,James F. Gusella,Marcy E. MacDonald +5 more
TL;DR: A major interactor class, comprising three distinct WW domain proteins, HYPA, HYPB and HYPC, that bind normal and mutant huntingtin in extracts of HD lymphoblastoid cells are identified, arguing that a WW domain-mediated process, such as non-receptor signaling, protein degradation or pre-mRNA splicing, may participate in HD pathogenesis.
Structure and expression of the Huntington's disease gene: Evidence against simple inactivation due to an expanded CAG repeat
Christine Ambrose,Mabel P. Duyao,Glenn Barnes,Gillian P. Bates,Carol Lin,Jayalakshmi Srinidhi,Sarah Baxendale,Holger Hummerich,Hans Lehrach,Michael R. Altherr,John J. Wasmuth,Alan Buckler,Deanna Church,David E. Housman,Mary Berks,Gos Micklem,Richard Durbin,Alan Dodge,Andrew P Read,James F. Gusella,Marcy E. MacDonald +20 more
TL;DR: Observations suggest that the dominant HD mutation either confers a new property on the mRNA or alters an interaction at the protein level, suggesting the operation of interacting factors in determining specificity of cell loss.
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The Huntington's disease candidate region exhibits many different haplotypes.
Marcy E. MacDonald,Andrea Novelletto,Carol Lin,Dan Tagle,Glenn Barnes,Gillian P. Bates,Sherry Taylor,Bernice A. Allitto,Michael R. Altherr,Richard H. Myers,Hans Lehrach,Francis S. Collins,John J. Wasmuth,Marina Frontali,James F. Gusella +14 more
TL;DR: Analysis of 78 Huntington's disease chromosomes with multi–allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations, and the most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D 4S182 and D4S180.
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