Giuseppe Starace
7 Papers
138 Citations
Giuseppe Starace is an academic researcher. The author has contributed to research in topics: Cell & Apoptosis. The author has an hindex of 7, co-authored 7 publications.
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Papers
Arrest of G(1)-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription.
Daniele Guardavaccaro,Giuseppina Corrente,Francesca Covone,Laura Micheli,Igea D'Agnano,Giuseppe Starace,Maurizia Caruso,Felice Tirone +7 more
TL;DR: It is reported that expression of PC3 in cycling cells induced accumulation of hypophosphorylated, growth-inhibitory forms of pRb and led to G1 arrest, and that PC3 acts, either directly or indirectly, as a transcriptional regulator of cyclin D1.
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•Journal Article
Overexpression of the nerve growth factor-inducible PC3 immediate early gene is associated with growth inhibition
TL;DR: It is reported that overexpression of PC3 in NIH3T3 and PC12 cells leads to marked inhibition of cell proliferation, the first evidence of a NGF-inducible immediate early gene displaying antiproliferative activity.
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Myc down-regulation induces apoptosis in M14 melanoma cells by increasing p27(kip1) levels.
Igea D'Agnano,Alessandra Valentini,Cristina Fornari,Barbara Bucci,Giuseppe Starace,Armando Felsani,Gennaro Citro +6 more
TL;DR: The results indicate that down-regulation of Myc protein induces a G1 arrest and activates apoptosis by increasing p27kip1 content in melanoma cells, that are known to be defective for the p16-cyclinD/cdk4-pRb G1 checkpoint.
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Cell-to-cell signaling influences the fate of prostate cancer stem cells and their potential to generate more aggressive tumors
Luisa Salvatori,Francesca Caporuscio,Alessandra Verdina,Giuseppe Starace,Stefania Crispi,Maria Rita Nicotra,Andrea Russo,Raffaele A. Calogero,Emanuela Morgante,Pier Giorgio Natali,Matteo Antonio Russo,Elisa Petrangeli +11 more
TL;DR: These findings show for the first time that CSC are able to generate differentiated cells expressing either highly or scarcely aggressive phenotype, thus influencing prostate cancer progression.
Human papillomavirus-16 E7 interacts with Siva-1 and modulates apoptosis in HaCaT human immortalized keratinocytes.
Anna Severino,Claudia Abbruzzese,Lucrezia Manente,Álvaro Avivar Valderas,Stefano Mattarocci,Antonio Federico,Giuseppe Starace,Alberto Chersi,Anna Maria Mileo,Marco G. Paggi +9 more
TL;DR: Being apoptosis a key physiological process for the elimination of irreversibly injured cells, the anti‐apoptotic role of HPV‐16 E7, performed at least by its interference with Siva‐1, can be considered an additional mechanism for the survival of damaged, potentially transforming, cell clones.
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