Giulia Romagnoli
Istituto Superiore di Sanità
33 Papers
301 Citations
Giulia Romagnoli is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Epitope & Dendritic cell. The author has an hindex of 16, co-authored 29 publications.
Chat about Author
Papers
3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells
Stefania Parlato,Adele De Ninno,Adele De Ninno,Rosa Molfetta,Elena Toschi,Debora Salerno,Arianna Mencattini,Giulia Romagnoli,Alessandra Fragale,Lorenzo Roccazzello,Maria Buoncervello,Irene Canini,Enrico Bentivegna,Mario Falchi,Francesca Romana Bertani,Annamaria Gerardino,Eugenio Martinelli,Corrado Di Natale,Rossella Paolini,Luca Businaro,Lucia Gabriele +20 more
TL;DR: This platform allowed the dissection of IFN-DC-cancer cell interactions within 3D tumor spaces, with the discovery of major underlying factors such as CXCR4 involvement and underscored its potential as an innovative tool to assess the efficacy of immunotherapeutic approaches.
161
Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1.
Crescenzo D'Alterio,Maria Buoncervello,Caterina Ieranò,Maria Napolitano,Luigi Portella,Giuseppina Rea,Antonio Barbieri,Antonio Luciano,Giosuè Scognamiglio,Fabiana Tatangelo,Anna Maria Anniciello,Mario Monaco,Ernesta Cavalcanti,Piera Maiolino,Giulia Romagnoli,Claudio Arra,Gerardo Botti,Lucia Gabriele,Stefania Scala +18 more
TL;DR: The effects of the human-anti-PD-1 nivolumab and/or Peptide-R54 (Pep R54), were evaluated on human melanoma PES43 cells and xenografts treated and the TME was evaluated through immunohistochemistry and flow-cytometry.
Mycobacterium tuberculosis subverts the differentiation of human monocytes into dendritic cells
Sabrina Mariotti,Raffaela Teloni,Elisabetta Iona,Lanfranco Fattorini,Federico Giannoni,Giulia Romagnoli,Graziella Orefici,Roberto Nisini +7 more
TL;DR: The results suggest that the interference with monocyte differentiation into fully competent DC is an evasion mechanism of M. tuberculosis that could contribute to its intracellular persistence by avoiding immune recognition.
91
The interaction of human dendritic cells with yeast and germ-tube forms of Candida albicans leads to efficient fungal processing, dendritic cell maturation, and acquisition of a Th1 response-promoting function.
Giulia Romagnoli,Roberto Nisini,Paola Chiani,Sabrina Mariotti,Raffaela Teloni,Antonio Cassone,Antonella Torosantucci +6 more
TL;DR: The findings highlight the induction of substantially similar functional patterns in human DCs encountering the different forms of growth of C. albicans, both seemingly activating the Th1‐type immunity which is characteristic of the healthy human subjects, naturally immunized and protected against the fungus.
67
ATP secreted by endothelial cells blocks CX3CL1-elicited natural killer cell chemotaxis and cytotoxicity via P2Y11 receptor activation
Stefania Gorini,Giulia Callegari,Giulia Romagnoli,Caterina Mammi,Domenico Mavilio,Giuseppe M.C. Rosano,Massimo Fini,Francesco Di Virgilio,Sara Gulinelli,Simonetta Falzoni,Andrea Cavani,Davide Ferrari,Andrea la Sala +12 more
TL;DR: Extracellular ATP regulates NK-cell cytotoxicity via P2Y₁⁁R activation, protecting ECs from CX₃CL1-elicited NK cell-mediated killing and point out the P2y₀₂�R as a potential target for pharmacologic intervention aimed at reducing NK-mediated vascular injury.
57