Giulia Bregola
5 Papers
1 Citations
Giulia Bregola is an academic researcher. The author has contributed to research in topics: Circulating tumor cell & Cancer. The author has an hindex of 2, co-authored 4 publications.
Chat about Author
Papers
Molecular profiling of single circulating tumor cells with diagnostic intention
Bernhard Polzer,Gianni Medoro,Sophie Pasch,Francesca Fontana,Laura Zorzino,Aurelia Pestka,Ulrich Andergassen,Franziska Meier-Stiegen,Zbigniew T. Czyż,Zbigniew T. Czyż,Barbara Alberter,Steffi Treitschke,Thomas Schamberger,M. Sergio,Giulia Bregola,Anna Doffini,Stefano Gianni,Alex Calanca,Giulio Signorini,Chiara Bolognesi,Arndt Hartmann,Peter A. Fasching,Maria T. Sandri,Brigitte Rack,Tanja Fehm,Giuseppe Giorgini,Nicolò Manaresi,Christoph Klein,Christoph Klein +28 more
TL;DR: Microheterogeneity analysis among individual CTCs uncovered pre‐existing cells resistant to ERBB2‐targeted therapies suggesting ongoing microevolution at late‐stage disease whose exploration may provide essential information for personalized treatment decisions and shed light into mechanisms of acquired drug resistance.
260
Isolation and genetic analysis of pure cells from forensic biological mixtures: The precision of a digital approach
Francesca Fontana,Cesare Rapone,Giulia Bregola,R. Aversa,A. de Meo,Giulio Signorini,M. Sergio,A. Ferrarini,Rossana Lanzellotto,Gianni Medoro,G. Giorgini,Nicolò Manaresi,Andrea Berti +12 more
TL;DR: This study reports here the development of an application-specific DEPArray™ workflow enabling the detection and recovery of pure homogeneous cell pools from simulated blood/saliva and semen/Saliva mixtures, providing full genetic match with genetic profiles of corresponding donors.
56
Abstract 1552: Image-based microchip sorting of pure, immuno-phenotypically defined subpopulations of tumor cells from tiny formalin-fixed paraffin embedded (FFPE) samples reveals their distinct genetic features
Chiara Bolognesi,Anna Doffini,Genny Buson,Rossana Lanzellotto,Giulio Signorini,Valeria Sero,Alex Calanca,Francesca Fontana,Rita Romano,Stefano Gianni,Giulia Bregola,Gianni Medoro,Raimo Tanzi,Giuseppe Giorgini,Hans Morreau,Massimo Barberis,Willem E. Corver,Nicolò Manaresi +17 more
TL;DR: Sorting tumor rare-cell subpopulations reveals their genetic characteristics, undetectable in unsorted samples, and the proposed workflow further enables reliable detection of quantitative traits such as CNVs.
1
RNA analysis on pure tumor cells sorted by DEPArray™ platform from enriched blood samples
Gianni Medoro,Francesca Fontana,Alex Calanca,C Bolognesi,Stefano Gianni,M. Sergio,M. Banzi,E. Peruzzi,G. Sardella,A Doffini,Giulia Bregola,G. Giorgini,Nicolò Manaresi +12 more
- 01 Jan 2011
TL;DR: This work has demonstrated that the DEPArrayTM platform enables the detection and isolation of pure circulating tumor cells from peripheral blood enriched by CellSearch®, for their genetic analysis following whole genome amplification.
Abstract 3364: Combined enrichment of plasma EpCAM-positive extracellular vesicles (EVs) and circulating tumor cells (CTCs) from a single tube of cancer patient blood samples, for subsequent molecular analysis
Giulia Bregola,Martina Masotti,Claudio Ratti,Francesco Picardo,Nicolò Manaresi,Francesca Fontana +5 more
TL;DR: Bregola et al. as mentioned in this paper presented a method based on the CellMag technology (Menarini Silicon Biosystems, MSB) to carry out parallel enrichment of EVs and CTCs from whole blood through an EpCAM-based magnetic enrichment.