Giulia Benedetti
Leiden University
12 Papers
7 Citations
Giulia Benedetti is an academic researcher from Leiden University. The author has contributed to research in topics: Tumor necrosis factor alpha & Proinflammatory cytokine. The author has an hindex of 9, co-authored 12 publications. Previous affiliations of Giulia Benedetti include University of Leeds & University of Lyon.
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Papers
Zinc and its role in immunity and inflammation
TL;DR: This review aims at describing the mechanisms involved in the regulation of Zn homeostasis and their effects on the immune response focusing on those which are implicated in the physiopathology of rheumatoid arthritis.
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Classical and Paradoxical Effects of TNF-α on Bone Homeostasis
TL;DR: The role of TNF-α in bone homeostasis seems to depend on the concentration and the differentiation state of the cell type used as well as on the exposure time as mentioned in this paper.
Microbial Drug Efflux Proteins of the Major Facilitator Superfamily
Massoud Saidijam,Giulia Benedetti,Qinghu Ren,Zhiqiang Xu,Christopher J. Hoyle,S.L. Palmer,Alison Ward,Kim E. Bettaney,Gerda Szakonyi,Johan Meuller,Scott Morrison,Martin K Pos,Patrick Butaye,Karl Walravens,Kate P. Langton,Richard B. Herbert,Ronald A. Skurray,Ronald A. Skurray,Ian T. Paulsen,John O'Reilly,Nicholas G. Rutherford,Melissa H. Brown,Melissa H. Brown,Roslyn M. Bill,Peter J. F. Henderson +24 more
TL;DR: A structural genomics approach for the amplified expression, purification and characterisation of prokaryotic drug efflux proteins of the 'Major Facilitator Superfamily' of transport proteins from Helicobacter pylori, Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, Bacillus subtilis, Brucella melitensis, Campylobacter jejuni and Neisseria meningitides is described.
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IL-17A and TNF-α Increase the Expression of the Antiapoptotic Adhesion Molecule Amigo-2 in Arthritis Synoviocytes
TL;DR: These findings support a model whereby cell–cell contact with immune cells and exposure to the combination of both inflammatory cytokines and HMGB1 in the joints of RA patients increases Amigo2 expression in synoviocytes in an ERK-dependent manner which, in turn, enhances cellular adhesion and promotes cell survival and cellular proliferation.
A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-α.
Giulia Benedetti,Sreenivasa Ramaiahgaris,Bram Herpers,Bob van de Water,Leo S. Price,Marjo de Graauw +5 more
TL;DR: A sensitive fluorescence-based in vitro assay for TNF-α-mediated nephrotoxicity screening using mouse immortalized proximal tubular epithelial cells (IM-PTECs) is developed and applied and can be used as an alternative assay for neph rotoxicity prediction in vitro.
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