Gitanjali Dharmadhikari
University of Bremen
8 Papers
33 Citations
Gitanjali Dharmadhikari is an academic researcher from University of Bremen. The author has contributed to research in topics: Diabetes mellitus & Inflammation. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Gitanjali Dharmadhikari include Royal Netherlands Academy of Arts and Sciences.
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Papers
Possible Role of Interleukin-1β in Type 2 Diabetes Onset and Implications for Anti-inflammatory Therapy Strategies
TL;DR: A model of interleukin-1β dynamics in order to explain principles of disease onset is developed and it is suggested that treatments targeting glucose bear the potential of stopping progression from pre-diabetes to overt type 2 diabetes.
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Interleukin-Targeted Therapy for Metabolic Syndrome and Type 2 Diabetes
TL;DR: The mechanisms involved in the inflammatory response during diabetes progression are explained with specific attention to the IL-1β signal effects influencing insulin action and insulin secretion insulin secretion.
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Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes.
Gitanjali Dharmadhikari,Gitanjali Dharmadhikari,Katharina Stolz,Michael Hauke,Noel G. Morgan,Ajit Varki,Eelco J.P. de Koning,Eelco J.P. de Koning,Sørge Kelm,Kathrin Maedler +9 more
TL;DR: It is reported that certain Sialic-acid-binding immunoglobulin-like-lectins (siglecs) are expressed in human pancreatic islets in a cell-type specific manner and restoration of human Siglec-7 expression may be a novel therapeutic strategy targeted to both inhibition of immune activation and preservation of β-cell function and survival.
Neutralizing Interleukin-1β (IL-1β) Induces β-Cell Survival by Maintaining PDX1 Protein Nuclear Localization
Amin Ardestani,Nadine S. Sauter,Federico Paroni,Gitanjali Dharmadhikari,Jae Hyoung Cho,Roberto Lupi,Piero Marchetti,Jose Oberholzer,Julie Kerr Conte,Kathrin Maedler +9 more
TL;DR: It is shown that nuclear localization of PDX1 is essential for a functional β- cell and provides a novel mechanism of the protective effect of IL-1 receptor antagonist on β-cell survival and function.
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Evaluation of Existing Methods for Human Blood mRNA Isolation and Analysis for Large Studies.
Anke Meyer,Federico Paroni,Kathrin Günther,Gitanjali Dharmadhikari,Wolfgang Ahrens,Sørge Kelm,Kathrin Maedler +6 more
TL;DR: This study confirms that it is not possible to mix or change sampling or extraction strategies during the same study because of large variations of RNA yield and expression levels.