Giorgia Santilli
University College London
56 Papers
513 Citations
Giorgia Santilli is an academic researcher from University College London. The author has contributed to research in topics: Genetic enhancement & Haematopoiesis. The author has an hindex of 21, co-authored 45 publications. Previous affiliations of Giorgia Santilli include University of Chieti-Pescara & University of Modena and Reggio Emilia.
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Papers
Lentiviral Vector-Mediated Correction of a Mouse Model of Leukocyte Adhesion Deficiency Type I.
Diego Leon-Rico,Montserrat Aldea,Raquel Sanchez-Baltasar,Cristina Mesa-Núñez,Julien Record,Siobhan O. Burns,Giorgia Santilli,Adrian J. Thrasher,Adrian J. Thrasher,Juan A. Bueren,Elena Almarza +10 more
TL;DR: Results support for the first time the use of hCD18-LVs for the treatment of LAD-I patients in clinical trials and demonstrate that the LV-mediated gene therapy completely restored neutrophil extravasation in response to inflammatory stimuli.
Enhancing Lentiviral and Alpharetroviral Transduction of Human Hematopoietic Stem Cells for Clinical Application
Juliane W. Schott,Diego Leon-Rico,Carolina B. Ferreira,Karen F. Buckland,Giorgia Santilli,Myriam Armant,Axel Schambach,Axel Schambach,Alessia Cavazza,Adrian J. Thrasher,Adrian J. Thrasher +10 more
TL;DR: Application of these defined culture and transduction conditions is likely to significantly improve ex vivo gene therapy manufacturing protocols for HSPCs and downstream clinical efficacy.
Assessment of Pre-Clinical Liver Models Based on Their Ability to Predict the Liver-Tropism of Adeno-Associated Virus Vectors
Adrian Westhaus,Marti Cabanes-Creus,Kimberley L. Dilworth,Erhua Zhu,D. Salas Gómez,Renina Gale Navarro,Anais K. Amaya,Suzanne Scott,Magdalena Kwiatek,Alexandra L. McCorkindale,Tara E. Hayman,Silke Frahm,Dany P. Perocheau,Bang Manh Tran,Elizabeth Vincan,Sharon L. Wong,Shafagh A. Waters,Laurence O. W. Wilson,Julien Baruteau,Sebastian Diecke,Gloria González-Aseguinolaza,Giorgia Santilli,Adrian J. Thrasher,Ian E. Alexander,Leszek Lisowski +24 more
TL;DR: A functional evaluation of six AAV vectors in twelve preclinical models of the human liver is reported, with the aim of uncovering which model is the most relevant for the selection of AAV capsid variant for safe and efficient transgene delivery to primary human hepatocytes.
Lentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice
Andrea Schejtman,Walmir Cutrim Aragão-Filho,Walmir Cutrim Aragão-Filho,Simon Clare,Marta Zinicola,Maren Weisser,Siobhan O. Burns,Siobhan O. Burns,Claire Booth,Claire Booth,Hubert B. Gaspar,David C. Thomas,Antonio Condino-Neto,Adrian J. Thrasher,Adrian J. Thrasher,Giorgia Santilli +15 more
TL;DR: Transduction with the pCCLCHIM-p 47phox vector efficiently restores p47phox expression and biochemical NADPH oxidase function in p47PHox-deficient human and murine cells, and potentially support the clinical development of a gene therapy approach using the p CCLCHim-p47ph Cox vector.
BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.
Danilo Perrotti,Vincenzo Cesi,Rossana Trotta,Clara Guerzoni,Giorgia Santilli,Kenneth Campbell,Angela Iervolino,Fabrizio Condorelli,Carlo Gambacorti-Passerini,Michael A. Caligiuri,Bruno Calabretta +10 more
TL;DR: It is shown that expression of BCR-ABL in myeloid precursor cells leads to transcriptional suppression of the granulocyte colony–stimulating factor receptor G-CSF-R (encoded by CSF3R), possibly through down-modulation of C/EBPα—the principal regulator of granulocytic differentiation.