Gints Kalniņš
Latvian Biomedical Research and Study centre
5 Papers
2 Citations
Gints Kalniņš is an academic researcher from Latvian Biomedical Research and Study centre. The author has contributed to research in topics: Glycoprotein & Chemistry. The author has an hindex of 3, co-authored 5 publications.
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Papers
Potent SARS-CoV-2 mRNA Cap Methyltransferase Inhibitors by Bioisosteric Replacement of Methionine in SAM Cosubstrate
Olga Bobiļeva,Raitis Bobrovs,Iveta Kaņepe,Liene Patetko,Gints Kalniņš,M. Sisovs,Anna L. Bula,Solveiga Grinberga,Ma̅rtiņš Borodušķis,Anna Ramata-Stunda,Nils Rostoks,Aigars Jirgensons,Kaspars Tars,Kristaps Jaudzems +13 more
TL;DR: This work designed potential SARS-CoV-2 MTase Nsp14 and Nsp16 inhibitors by using bioisosteric substitution of the sulfonium and amino acid substructures of the cosubstrate S-adenosylmethionine (SAM), which serves as the methyl donor in the enzymatic reaction.
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Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications
Nadide Altincekic,Sophie Marianne Korn,Nusrat S. Qureshi,Marie Dujardin,Martí Ninot-Pedrosa,Rupert Abele,Marie Jose Abi Saad,Caterina Alfano,Fabio C. L. Almeida,Islam Alshamleh,Gisele Cardoso Amorim,Thomas K. Anderson,Cristiane D. Anobom,Chelsea Anorma,Jasleen Kaur Bains,Adriaan Bax,Martin Blackledge,Julius Blechar,Anja Böckmann,Louis Brigandat,Anna Bula,Matthias Bütikofer,Aldo R. Camacho-Zarco,Teresa Carlomagno,Ícaro Putinhon Caruso,Ícaro Putinhon Caruso,Betül Ceylan,Apirat Chaikuad,Apirat Chaikuad,Feixia Chu,Laura Cole,Marquise G. Crosby,Vanessa de Jesus,Karthikeyan Dhamotharan,Isabella C. Felli,Jan Ferner,Yanick Fleischmann,Marie-Laure Fogeron,Nikolaos K. Fourkiotis,Christin Fuks,Boris Fürtig,Angelo Gallo,Santosh Lakshmi Gande,Juan Atilio Gerez,Dhiman Ghosh,Francisco Gomes-Neto,Francisco Gomes-Neto,Oksana Gorbatyuk,Serafima Guseva,Carolin Hacker,Sabine Häfner,Bing Hao,Bruno Hargittay,Katherine A. Henzler-Wildman,Jeffrey C. Hoch,Katharina F. Hohmann,Marie T. Hutchison,Kristaps Jaudzems,Katarina Jović,Janina Kaderli,Gints Kalniņš,Iveta Kaņepe,Robert N. Kirchdoerfer,John Kirkpatrick,Stefan Knapp,Stefan Knapp,Robin Krishnathas,Felicitas Kutz,Susanne zur Lage,Roderick Lambertz,Andras Lang,Douglas V. Laurents,Lauriane Lecoq,Verena Linhard,Frank Löhr,Anas Malki,Luiza Mamigonian Bessa,Rachel W. Martin,Tobias Matzel,Damien Maurin,Seth W. McNutt,Nathane C. Mebus-Antunes,Beat H. Meier,Nathalie Meiser,Miguel Mompeán,Elisa Monaca,Roland Montserret,Laura Mariño Perez,Celine Moser,Claudia Muhle-Goll,Thais Cristtina Neves-Martins,Xiamonin Ni,Xiamonin Ni,Brenna Norton-Baker,Roberta Pierattelli,Letizia Pontoriero,Yulia Pustovalova,Oliver Ohlenschläger,Julien Orts,Andrea T. Da Poian,Dennis J. Pyper,Christian Richter,Roland Riek,Chad M. Rienstra,Angus J. Robertson,Anderson S. Pinheiro,Raffaele Sabbatella,Nicola Salvi,Krishna Saxena,Linda Schulte,Marco Schiavina,Harald Schwalbe,Mara Silber,Marcius S. Almeida,Marc A. Sprague-Piercy,Georgios A. Spyroulias,Sridhar Sreeramulu,Jan-Niklas Tants,Kaspars Tārs,Felix Torres,Sabrina Töws,Miguel A. Treviño,Sven Trucks,Aikaterini C. Tsika,Krisztina Varga,Ying Wang,Marco E. Weber,Julia E. Weigand,Christoph Wiedemann,Julia Wirmer-Bartoschek,Maria Alexandra Wirtz Martin,Johannes Zehnder,Martin Hengesbach,Andreas Schlundt +133 more
TL;DR: In this paper, the authors present an extensive catalog of a holistic SARS-CoV-2 protein preparation approach based on the COVID19-NMR consortium's collective efforts.
N-Terminal Modification of Gly-His-Tagged Proteins with Azidogluconolactone.
Karl D. Brune,Ilva Liekniņa,Grigorij Sutov,Alexander R Morris,Dejana Jovicevic,Gints Kalniņš,Andris Kazāks,Rihards Kluga,Sabine Kastaljana,Anna Zajakina,Juris Jansons,Dace Skrastiņa,Karīna Spunde,Alexander A. Cohen,Pamela J. Bjorkman,Howard R. Morris,Edgars Suna,Kaspars Tārs,Kaspars Tārs +18 more
TL;DR: Azidogluconoylation is simple, fast and robust chemistry, and should accelerate research and development as mentioned in this paper, which is a non-enzymatic, post-translational modification of N-terminal HisTags.
Three-dimensional structure of 22 uncultured ssRNA bacteriophages: Flexibility of the coat protein fold and variations in particle shapes.
Jānis Rūmnieks,Ilva Liekniņa,Gints Kalniņš,M. Sisovs,Ināra Akopjana,Jānis Bogans,Kaspars Tārs +6 more
TL;DR: Rec recombinantly expressed metagenome-derived ssRNA phage CPs to produce virus-like particles and determined the three-dimensional structure of 22 previously uncharacterized ss RNA phage capsids covering nine distinct CP types, expanding the knowledge of the evolution of viral structural proteins.
Production and characterization of novel ssRNA bacteriophage virus-like particles from metagenomic sequencing data.
Ilva Liekniņa,Gints Kalniņš,Ināra Akopjana,Jānis Bogans,M. Sisovs,Juris Jansons,Jānis Rūmnieks,Kaspars Tārs +7 more
TL;DR: Compared to the few types of ssRNA phage VLPs that were used before, several dozens of new particles representing ten distinct similarity groups are now available with a notable potential for biotechnological applications.