Gin Den Chen

TL;DR: Depression-like behavior is associated with remarkable reduction in glutamatergic, but not GABAergic, transmission in the vlPAG, and this cellular mechanism may be a critical component in the pathogenesis of stress-associated neuropsychiatric disorders.

TL;DR: Progesterone is capable of producing GABAARs‐dependent inhibition of the induction of spinal reflex potentiation by actions through neurosteroid metabolites, implying that progesterone‐mediated effects on GABAAR expression and neural inhibition are regulated by neurosteroids synthesis rather than progester one receptor activation.

TL;DR: Results suggested that Cdk‐dependent NMDAR NR2B subunit phosphorylation mediates the development of cross‐organ pelvic–urethra reflex sensitization caused by acute colon irritation which could possibly underlie the high concurrence of pelvic pain syndrome with irritable bowel syndrome.

TL;DR: The results suggest that estrogen levels might modulate the cross-organ sensitization between the uterus and the urethra and underlie the high concurrence of pelvic pain syndrome and LUT dysfunctions.