Ampicillin/sulbactam is a beta-lactam/beta-lactamase inhibitor combination with a broad spectrum of antibacterial activity against Gram-positive, Gram-negative and anaerobic bacteria. Data from comparative studies justify the use of ampicillin/sulbactam in a 2 : 1 ratio in various severe bacterial infections. In comparative clinical trials, ampicillin/sulbactam has proved to be a significant drug in the therapeutic armamentarium for lower respiratory tract infections and aspiration pneumonia, gynaecological/obstetrical infections, intra-abdominal infections, paediatric infections such as acute epiglottitis and periorbital cellulitis, diabetic foot infections, and skin and soft tissue infections. Of particular interest during this era of increasing antimicrobial resistance in various settings and populations is the effectiveness of sulbactam against a considerable proportion of infections due to Acinetobacter baumannii.

Ampicillin/sulbactam: current status in severe bacterial infections.

http://ntur.lib.ntu.edu.tw/bitstream/246246/155918/1/45.pdf

Prognosis of adult patients with bacteremia caused by extensively resistant Acinetobacter baumannii.

Meropenem (MEM; 2 g/8 hr; minimum inhibitory concentration [MIC] = 256 mg/L) plus sulbactam (SUL; 1 g/8 hr; MIC = 128 mg/L) (two-drug–therapy period), and subsequent additional intravenous colistin (COL; 2.5 mg/kg/12 hr) and intraventricular (COL, 5 mg/day; MIC = 1 mg/L) (three-drug–therapy period) were sequentially used in a patient with postneurosurgery bacteremic meningitis due to a multidrug-resistant Acinetobacter baumannii (MDRAB) isolate (AB1). We detected 4- to 32-fold increases in peak or trough cerebrospinal fluid bactericidal titer and serum bactericidal titer in three-drug–therapy period when comparing to those in two-drug–therapy period. The time-kill study with MEM, SUL, and COL alone or varied combinations (all at 1 × MIC) against AB1 and another genetically nonrelated MDRAB isolate (AB134 [MICs of MEM = 64 mg/L, SUL = 16 mg/L, and COL = 1 mg/L]) was performed. The two-drug combinations (MEM + SUL, MEM + COL, and SUL + COL) each elicited different inhibitory effect on AB1 and AB134 at 6 hr....

http://www.dxy.cn/topic/mp_pdf/Antimicrobial_effects_of_varied_combinations.pdf

Antimicrobial effects of varied combinations of meropenem, sulbactam, and colistin on a multidrug-resistant Acinetobacter baumannii isolate that caused meningitis and bacteremia.

ary initiatives were initially directed toward surgical site infection, ventilator-associated pneumonia, and bloodstream infection. The fourth leg of the tetrad of major hospital-acquired infections urinary tract infection has received relatively little attention. This neglect seems exceptional, because urinary infection is the single most common hospital-acquired infection [1]. Health care-acquired urinary infection is a substantial burden for patients and the health care system [ 1 ] . They constitute 40% of all hospital-acquired infections, and fully 80% of these infections are attributable to indwelling urethral catheter use. Twelve percent to 16% of hospital inpatients will have an indwelling catheter placed at some time during hospitalization. While the catheter remains in situ,

/pdf/the-prevention-of-hospital-acquired-urinary-tract-infection-3hzxzqku41.pdf

The Prevention of Hospital-Acquired Urinary Tract Infection

Aim Efficacy of colistin and ampicillin-sulbactam have not been compared in treatment of ventilator-associated pneumonia due to A baumannii Efficacy of colistin and ampicillin-sulbactam in combination with meropenem were compared in treatment of ventilator-associated pneumonia due to carbapenem-resistant A baumannii Method 47 patients with ventilator-associated pneumonia due to carbapenem-resistant A baumannii were randomized to receive meropenem/colistin or meropenem/ampicillin-sulbactam for 14 days Clinical and microbiological responses and 28-day mortality were considered as outcomes Results Clinical response (75 vs 696%; p = 075) and microbial eradication (8750 vs 913%; p = 059) were comparable between meropenem/colistin and meropenem/ampicillin-sulbactam groups, respectively Conclusion In this study, clinical and microbiological response were comparable between the meropenem/colistin and meropenem/ampicillin-sulbactam groups

Meropenem/colistin versus meropenem/ampicillin-sulbactam in the treatment of carbapenem-resistant pneumonia.

Outbreaks of Serratia marcescens bacteriuria in a neurosurgical intensive care unit of a tertiary care teaching hospital: a clinical, epidemiologic, and laboratory perspective

Synergic in-vitro activity of imipenem and sulbactam against Acinetobacter baumannii

Mortality risk factors of Acinetobacter baumannii bacteraemia

Coccidioidomycosis results from inhaling the spores (arthroconidia) of Coccidioides species (Coccidioides immitis or Coccidioides posadasii), and is endemic in the southern United States. An even smaller proportion of all infections result in illnesses related to extrapulmonary infection. We report a case of coccidioidomycosis manifested as pelvic bone and paravertebral abscess in a Korean who has visited LA. Culture and pathology from the pelvic bone and paravertebral mass revealed Coccidioides immitis, and a diagnosis of disseminated coccidioidomycosis was made.

A Case of Disseminated Coccidioidomycosis with Pelvic Bone and Paravertebral Abscess

https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/109286/1/T200600436.pdf

Bilateral peripheral facial palsy in a patient with human immunodeficiency virus (HIV) infection

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