ary initiatives were initially directed toward surgical site infection, ventilator-associated pneumonia, and bloodstream infection. The fourth leg of the tetrad of major hospital-acquired infections urinary tract infection has received relatively little attention. This neglect seems exceptional, because urinary infection is the single most common hospital-acquired infection [1]. Health care-acquired urinary infection is a substantial burden for patients and the health care system [ 1 ] . They constitute 40% of all hospital-acquired infections, and fully 80% of these infections are attributable to indwelling urethral catheter use. Twelve percent to 16% of hospital inpatients will have an indwelling catheter placed at some time during hospitalization. While the catheter remains in situ,

/pdf/the-prevention-of-hospital-acquired-urinary-tract-infection-3hzxzqku41.pdf

The Prevention of Hospital-Acquired Urinary Tract Infection

Aim Efficacy of colistin and ampicillin-sulbactam have not been compared in treatment of ventilator-associated pneumonia due to A baumannii Efficacy of colistin and ampicillin-sulbactam in combination with meropenem were compared in treatment of ventilator-associated pneumonia due to carbapenem-resistant A baumannii Method 47 patients with ventilator-associated pneumonia due to carbapenem-resistant A baumannii were randomized to receive meropenem/colistin or meropenem/ampicillin-sulbactam for 14 days Clinical and microbiological responses and 28-day mortality were considered as outcomes Results Clinical response (75 vs 696%; p = 075) and microbial eradication (8750 vs 913%; p = 059) were comparable between meropenem/colistin and meropenem/ampicillin-sulbactam groups, respectively Conclusion In this study, clinical and microbiological response were comparable between the meropenem/colistin and meropenem/ampicillin-sulbactam groups

Meropenem/colistin versus meropenem/ampicillin-sulbactam in the treatment of carbapenem-resistant pneumonia.

We report the findings of an active surveillance scheme for detection of asymptomatic carriers with carbapenemase-producing Gram-negative bacteria (CP-GNB) in Romanian hospitals. During a pilot study from December 2014 to May 2015, faecal cultures were screened in three hospitals (two large, one medium-size) for patients newly admitted to selected wards or inpatients transferred from other wards to an intensive-care unit. The study revealed a high prevalence of CP-GNB detected in 22/27 and 28/38 of the carbapenem non-susceptible isolates from Hospitals 1 and 3, respectively. CP-GNB identified through faecal screening included NDM-1-producing Serratia marcescens and Klebsiella pneumoniae, OXA-48-producing K. pneumoniae and OXA-23-producing Acinetobacter baumannii. The distribution of the CP-GNB varied between the hospitals, with NDM-1-producing S. marcescens and K. pneumoniae being prevalent in the north-central part of the country and OXA-23/24-producing A. baumannii, OXA-48-producing K.pneumoniae, Morganella morganii and VIM-2-producing Escherichia coli/Pseudomonas aeruginosa detected in the north-east of the country. Conjugation studies showed that carbapenem resistance was transferable and PCR-based replicon typing identified blaNDM-1 on IncFIIs in S. marcescens and K. pneumoniae from Hospital 1 and blaOXA-48 on IncL plasmids in all Klebsiella spp. isolates from Hospitals 1 and 3. Our findings underline the importance of active surveillance for detection of CP-GNB asymptomatic faecal carriers and suggest a likely endemic spread of CP-GNB in Romania.

/pdf/active-surveillance-scheme-in-three-romanian-hospitals-20l9dkucqz.pdf

Active surveillance scheme in three Romanian hospitals reveals a high prevalence and variety of carbapenamase-producing Gram-negative bacteria: a pilot study, December 2014 to May 2015.

Effects of Bacillus Serine Proteases on the Bacterial Biofilms

Serratia marcescens is a well recognized nosocomial pathogen We report an outbreak with this organism in 8 neonates in a neonatal intensive care unit (NICU) Seven cases were treated successfully with meropenem after the failure of imipenem treatment Although they have similar anti-microbial effects, meropenem can effectively treat the S marcescens sepsis resistant to imipenem

/pdf/an-outbreak-of-serratia-marcescens-septicemia-in-neonates-j4ja9mq4iy.pdf

An outbreak of Serratia marcescens septicemia in neonates.

Outbreaks of Serratia marcescens bacteriuria in a neurosurgical intensive care unit of a tertiary care teaching hospital: a clinical, epidemiologic, and laboratory perspective

Mortality risk factors of Acinetobacter baumannii bacteraemia

Correlation between Adherence to Antiretroviral Treatment and Virologic Failure in HIV-infected Koreans

Low plasma levels of the soluble receptor for advanced glycation end products in HIV-infected patients with subclinical carotid atherosclerosis receiving combined antiretroviral therapy

https://ir.ymlib.yonsei.ac.kr/bitstream/22282913/93320/1/T201101521.pdf

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