Gilles J. Guillemin
Macquarie University
378 Papers
1K Citations
Gilles J. Guillemin is an academic researcher from Macquarie University. The author has contributed to research in topics: Kynurenine pathway & Quinolinic acid. The author has an hindex of 70, co-authored 341 publications. Previous affiliations of Gilles J. Guillemin include Sultan Qaboos University & Australian School of Advanced Medicine.
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Papers
Characterization of the kynurenine pathway in human oligodendrocytes
Chai K. Lim,George A. Smythe,Roland Stocker,Bruce J. Brew,Gilles J. Guillemin,Gilles J. Guillemin +5 more
- 01 Nov 2007
TL;DR: Results indicate that human oligodendrocytes are more likely to produce neuroprotective KP metabolites such as KYNA and PIC rather than QUIN, and that because of the lack of IDO they are not able to down-regulate the immune response and as such may be more vulnerable to autoimmune phenomena.
Effects of Kynurenine Pathway Inhibition on NAD+ Metabolism and Cell Viability in Human Primary Astrocytes and Neurons
Nady Braidy,Gilles J. Guillemin,Ross Grant,Ross Grant +3 more
- 08 May 2011
TL;DR: The hypothesis that the primary role of KP activation during neuroinflammation is to maintain NAD+ levels through de novo synthesis from TRP is supported, unless alternative precursors for NAD+ synthesis are made available.
Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection
Gilles J. Guillemin,Stephen J. Kerr,George A. Smythe,Danielle G. Smith,Vimal Kapoor,Patricia J. Armati,Juliana Croitoru,Bruce J. Brew +7 more
TL;DR: It is shown that kynurenine in concentrations comparable with those produced by astrocytes led to significant production of QUIN by macrophages, suggesting that astroCytes alone are neuroprotective by minimizing QUIN production and maximizing synthesis of kynurenic acid.
Kynurenine, tetrahydrobiopterin, and cytokine inflammatory biomarkers in individuals affected by diabetic neuropathic pain
Ananda Staats Pires,Ananda Staats Pires,Benjamin Heng,Vanessa Tan,Alexandra Latini,Marc Russo,Danielle M. Santarelli,Dominic Bailey,Katie Wynne,Katie Wynne,Jayden A. O’Brien,Gilles J. Guillemin,Paul J. Austin +12 more
TL;DR: This study supports the idea that inflammatory activation of the KYN and BH4 pathways occurs due to elevated inflammatory cytokines, which might be involved in the pathogenesis of neuropathic pain in type 1 diabetes mellitus.
Sphingosine 1-phosphate but not Fingolimod protects neurons against excitotoxic cell death by inducing neurotrophic gene expression in astrocytes.
Collin Tran,Collin Tran,Benjamin Heng,Jonathan D. Teo,Sean J. Humphrey,Yanfei Qi,Timothy A. Couttas,Holly Stefen,Merryn Brettle,Thomas Fath,Thomas Fath,Gilles J. Guillemin,Anthony S. Don +12 more
TL;DR: It is shown that S1P protects hippocampal neurons against excitotoxic cell death through up‐regulation of neurotrophic gene expression, particularly LIF, in astrocytes, and requires both S1 PR1 and S1PR2 signaling.