Gilles J. Guillemin
Macquarie University
378 Papers
1K Citations
Gilles J. Guillemin is an academic researcher from Macquarie University. The author has contributed to research in topics: Kynurenine pathway & Quinolinic acid. The author has an hindex of 70, co-authored 341 publications. Previous affiliations of Gilles J. Guillemin include Sultan Qaboos University & Australian School of Advanced Medicine.
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Papers
Bcl11b: A New Piece to the Complex Puzzle of Amyotrophic Lateral Sclerosis Neuropathogenesis?
Matthew J. Lennon,Simon Jones,Michael D. Lovelace,Gilles J. Guillemin,Bruce J. Brew,Bruce J. Brew +5 more
TL;DR: This review explores the rationale for the involvement of a novel protein, B-cell lymphoma/leukaemia 11b (Bcl11b) in ALS, and its functions in neurodevelopment, viral latency and T-cell development suggest potential roles in ALS pathology.
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Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons.
Nady Braidy,Bruce J. Brew,Nibaldo C. Inestrosa,Nibaldo C. Inestrosa,Roger S. Chung,Perminder S. Sachdev,Gilles J. Guillemin +6 more
TL;DR: Results suggest that induction of deficits in CatD and Bc1 is a significant mechanism for QUIN toxicity in glial and neuronal cells, and maintenance of autophagy may play a crucial role in neuroprotection in the setting of AD.
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Food and your mood: Nutritional psychiatry
TL;DR: The examples outlined are convincing and are of clinical and scientific importance and underline the importance of nutrition and dietary factors to psychiatric illnesses and mental health.
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Could the kynurenine pathway be the key missing piece of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) complex puzzle?
Bahar Kavyani,Brett A. Lidbury,Richard Schloeffel,Paul Fischer,Daniel Missailidis,Sarah J. Annesley,Mona Dehhaghi,Benjamin Heng,Gilles J. Guillemin +8 more
TL;DR: In this article , the authors discuss the pathology and management of ME/CFS and provide evidence pertaining kynurenine pathway abnormalities and symptoms that are classic characteristics of ME and CFS.
Mechanisms of l-Serine Neuroprotection in vitro Include ER Proteostasis Regulation
TL;DR: It is proposed that l-serine may be functioning as a small proteostasis regulator, in effect altering the cells to quickly respond to a possible oxidative insult, thus favoring a return to homeostasis.
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