Gilles J. Guillemin
Macquarie University
378 Papers
1K Citations
Gilles J. Guillemin is an academic researcher from Macquarie University. The author has contributed to research in topics: Kynurenine pathway & Quinolinic acid. The author has an hindex of 70, co-authored 341 publications. Previous affiliations of Gilles J. Guillemin include Sultan Qaboos University & Australian School of Advanced Medicine.
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Papers
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
TL;DR: The kynurenine (KYN) pathway of tryptophan (TRP) metabolism is dysregulated in inflammation-driven pathologies including oncological and brain diseases.
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Neuroprotective Effects of Rosmarinic Acid on Ciguatoxin in Primary Human Neurons
Nady Braidy,A. Matin,Fanny Rossi,Mireille Chinain,Dominique Laurent,Dominique Laurent,Gilles J. Guillemin +6 more
TL;DR: It is shown that pre- and post-treatment with rosmarinic acid (RA), the active constituent of the Heliotropium foertherianum (Boraginaceae) can attenuate CTX-mediated neurotoxicity, and this results further highlight the potential of RA in the treatment ofCTX-induced neurological deficits.
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Kynurenine pathway modulation reverses the experimental autoimmune encephalomyelitis mouse disease progression.
TL;DR: It is shown that the KP was steadily upregulated correlating with disease severity and associated with a shift towards increasing concentrations of the KP metabolite quinolinic acid, a neuro- and gliotoxin, which provides a new mechanistic link between neuroinflammation and neurodegeneration in EAE.
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: Amelioration by COX-2 inhibition
Katerina Zavitsanou,Chai K. Lim,Tertia D. Purves-Tyson,Tim Karl,Michael Kassiou,Samuel D. Banister,Gilles J. Guillemin,Cynthia Shannon Weickert +7 more
TL;DR: The blood kynurenine pathway is revealed as a potential mechanism by which MIA interferes with postnatal brain maturation and associated behavioural disturbances and emphasises the preventative potential of inflammation targeting drugs.
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Chemical reprogramming enhances homology-directed genome editing in zebrafish embryos.
Yagiz Alp Aksoy,Yagiz Alp Aksoy,David T. Nguyen,Sharron Chow,Roger S. Chung,Gilles J. Guillemin,Nicholas J. Cole,Daniel Hesselson,Daniel Hesselson +8 more
- 23 May 2019
TL;DR: An in vivo visual reporter assay is developed to quantify HDR-mediated events at single-cell resolution in zebrafish and a system is used to identify small-molecule modulators that shift the DNA repair equilibrium in favor of HDR.