Gilean McVean
University of Oxford
77 Papers
1.2K Citations
Gilean McVean is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Biology. The author has an hindex of 42, co-authored 77 publications. Previous affiliations of Gilean McVean include University of Cambridge & University of Edinburgh.
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Papers
Molecular evolution of imprinted genes: no evidence for antagonistic coevolution
Gilean McVean,Laurence D. Hurst +1 more
TL;DR: Contrary to the expectations of the conflict hypothesis, there is no evidence for antagonistic coevolution of imprinted genes mediated by changes in sequence.
A Genealogical Interpretation of Linkage Disequilibrium
TL;DR: It is shown that the effects of population growth, population bottlenecks, and population structure on linkage disequilibrium can be described through their effects on the covariance in coalescence times.
Neutral evolution of the sex-determining gene transformer in Drosophila.
TL;DR: Both levels of analysis of the tra sequence suggest that, although the gene is evolving at a rapid pace, these changes are neutral in function.
Bayesian meta-analysis across genome-wide association studies of diverse phenotypes
Holly Trochet,Holly Trochet,Matti Pirinen,Matti Pirinen,Gavin Band,Luke Jostins,Gilean McVean,Chris C. A. Spencer +7 more
TL;DR: MetABF, a simple Bayesian framework for performing integrative meta-analysis across multiple GWAS using summary statistics, is described, which can increase the power by 50% compared to standard frequentist tests when only a subset of studies have a true effect.
Germs, genomes and genealogies
TL;DR: It is shown how simple epidemiological models can be related to the ancestral, or coalescent, process underlying samples from pathogen species, enabling detailed inference about pathogen biology from patterns of molecular variation.