Gilean McVean
University of Oxford
77 Papers
1.2K Citations
Gilean McVean is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Biology. The author has an hindex of 42, co-authored 77 publications. Previous affiliations of Gilean McVean include University of Cambridge & University of Edinburgh.
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Papers
Low-bias rna sequencing of the hiv-2 genome from blood plasma.
K James,K James,Thushan I de Silva,Thushan I de Silva,Katherine A. Brown,Hilton Whittle,Stephen Taylor,Gilean McVean,Joakim Esbjörnsson,Joakim Esbjörnsson,Sarah Rowland-Jones +10 more
TL;DR: This study demonstrates that RNA-Seq is a feasible full-genome de novo sequencing method for blood plasma samples collected from HIV-2-infected individuals.
Estimating Diversifying Selection and Functional Constraint in the Presence of Recombination
Daniel J. Wilson,Gilean McVean +1 more
TL;DR: This work presents a model that uses a population genetics approximation to the coalescent with recombination and use reversible-jump MCMC to perform Bayesian inference on both the dN/dS ratio and the recombination rate, allowing each to vary along the sequence.
Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome.
Jianbing Mu,Philip Awadalla,Junhui Duan,Kate M. McGee,Jon Keebler,Karl B. Seydel,Gilean McVean,Xin-zhuan Su +7 more
TL;DR: The authors of as mentioned in this paper surveyed 3,539 P. falciparum genes (approximately 65% of the predicted genes) for polymorphisms and identified various highly polymorphic loci and genes, some of which encoded new antigens that were confirmed using human immune sera.
Evidence for a selectively favourable reduction in the mutation rate of the X chromosome.
Gilean McVean,Laurence D. Hurst +1 more
TL;DR: This hypothesis that selection will often favour a lower mutation rate on the X chromosome than on autosomes, owing to the exposure of deleterious recessive mutations on hemizygous chromosomes is tested by examining 33 X-linked genes that have been sequenced in both mouse and rat, and compared their rate of evolution against 238 autosomal genes.
Comparison of Fine-Scale Recombination Rates in Humans and Chimpanzees
Wendy Winckler,Simon Myers,Daniel J. Richter,Robert C. Onofrio,Gavin J. McDonald,Ronald E. Bontrop,Gilean McVean,Stacey Gabriel,David Reich,Peter Donnelly,David Altshuler +10 more
TL;DR: Local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence, in humans and chimpanzees, by analyzing polymorphism data in both species.