Gilean McVean
University of Oxford
77 Papers
1.2K Citations
Gilean McVean is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Biology. The author has an hindex of 42, co-authored 77 publications. Previous affiliations of Gilean McVean include University of Cambridge & University of Edinburgh.
Chat about Author
Papers
Selfish mutations dysregulating RAS-MAPK signaling are pervasive in aged human testes
Geoffrey J. Maher,Hannah K Ralph,Zhihao Ding,Nils Koelling,Hana Mlcochova,Eleni Giannoulatou,Pawan Dhami,Dirk S. Paul,Stefan H. Stricker,Stephan Beck,Gilean McVean,Andrew O.M. Wilkie,Anne Goriely +12 more
TL;DR: The link between mutations dysregulating the RAS-MAPK pathway and selfish selection is extended, and it is shown that the aging male germline is a repository for such deleterious mutations.
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases
John D. Rioux,John D. Rioux,Philippe Goyette,Philippe Goyette,Timothy J. Vyse,Lennart Hammarström,Michelle M. A. Fernando,Todd Green,Philip L. De Jager,Philip L. De Jager,Sylvain Foisy,Sylvain Foisy,Joanne Wang,Paul I.W. de Bakker,Stephen Leslie,Gilean McVean,Leonid Padyukov,Lars Alfredsson,Vito Annese,David A. Hafler,Qiang Pan-Hammarström,Ritva Matell,Stephen Sawcer,Alastair Compston,Bruce A.C. Cree,Daniel B. Mirel,Mark J. Daly,Timothy W. Behrens,Lars Klareskog,Peter K. Gregersen,Jorge R. Oksenberg,Stephen L. Hauser +31 more
TL;DR: The data demonstrate that MHC associations with autoimmune diseases result from complex, multilocus effects that span the entire region.
A population genetic model for the evolution of synonymous codon usage: patterns and predictions
Gilean McVean,Brian Charlesworth +1 more
TL;DR: This new model is used to explore the relationships between synonymous codon usage, nucleotide site diversity and the rate of substitution, and derive the equilibrium frequency distribution of weakly selected segregating sites under the infinite-sites model, and the expected nucleotideSite diversity.
Recombination hotspots and population structure in Plasmodium falciparum.
Jianbing Mu,Philip Awadalla,Junhui Duan,Kate M. McGee,Deirdre A. Joy,Gilean McVean,Xin-zhuan Su +6 more
TL;DR: This study supports the feasibility of genome-wide association studies in some parasite populations by describing the first chromosome-wide SNP haplotype and population recombination maps for a global collection of malaria parasites, including the 3D7 isolate, whose genome has been sequenced previously.
What do patterns of genetic variability reveal about mitochondrial recombination
TL;DR: It is shown that measures differ in the way they treat data that are uninformative about recombination, and that the significant negative correlation between linkage disequilibrium and distance, in at least some of the data sets, is a real pattern that requires explanation.