Gigi Pg
3 Papers
Gigi Pg is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has co-authored 2 publications.
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Papers
Comparison of Teriparatide and Combination of Cissus Quadrangularis and Dalbergia Sissoo on Bone Healing Against the Control Group in Maxillofacial Fractures: A Randomized Open-label Control Trial
Gigi Pg,Ankita Chugh,Kirti Chaudhry,Amanjot Kaur,Pravin H. P. Kumar,Shubham Gaur,Shailendra Kumar,Surjit Singh +7 more
TL;DR: In this article , a randomized control trial was planned to assess whether subcutaneous Injection of Teriparatide and Tablet Reunion (combination of Cissus Quadrangularis and Dalbergia sissoo) improves maxillofacial fracture healing as compared to the control group.
Topical 0.02% mitomycin in postoperative healing of oral submucous fibrosis treated with fibrous band release and buccal fat pad reconstruction: a pilot split-mouth study.
Ankita Chugh,Amanjot Kaur,Gigi Pg +2 more
Abstract: Topical application of 0.02% Mitomycin-C (MMC) has demonstrated efficacy in reducing fibrosis in ophthalmic and laryngeal procedures. This pilot study aimed to evaluate the potential role of MMC in enhancing healing outcomes in patients with Oral Submucous Fibrosis (OSMF) following surgical release of fibrous bands and reconstruction with the Buccal Fat Pad (BFP). A prospective, double-blinded, split-mouth feasibility pilot study was conducted on 10 patients diagnosed with OSMF. Each patient underwent surgical release of fibrous bands and/or coronoidectomy under general anaesthesia, followed by BFP reconstruction bilaterally. The right buccal mucosa (study side) received topical application of 0.02% MMC (0.2 mg/ml) twice, first, for 5 min over the raw surgical site before BFP placement, and again after 10 days for 3 min over the healing mucosa. The left side (control) received a placebo (normal saline) following the same protocol. Patients were assessed over three months for mucosal pliability, cheek flexibility, mucosal colouration and mouth opening. However, despite the theoretical antifibrotic potential of MMC, no statistically significant difference was observed between the MMC-treated and control sides with respect to mucosal pliability or cheek flexibility at any postoperative interval. Although preoperative cheek flexibility (4 ± 0.67 mm) demonstrated initial postoperative improvement, this was not sustained during follow-up, and the MMC application did not confer any measurable long-term advantage over placebo. Additionally, mucosal coloration remained stable and comparable on both sides, indicating no clinically discernible enhancement in mucosal healing attributable to MMC. Notably, no adverse tissue reactions or complications were associated with MMC use, supporting its local biocompatibility. Postoperative mouth opening showed significant improvement from a baseline of 16 ± 2.79 mm to 38.4 ± 1.58 mm at 1 week (T1), 36.1 ± 1.85 mm at 1 month (T2), and 33 ± 2.11 mm at 3 months (T3). These findings suggest that while MMC is safe for intraoral application at this concentration, its therapeutic efficacy in mitigating fibrosis in the OSMF surgical site remains inconclusive, warranting further investigation through larger, controlled trials. Clinical Trials Registry- India registration (CTRI/2022/04/041738) dated 08/04/2022).